Inhibitors | Comment | Organism | Structure |
---|---|---|---|
chaetocin | specific isoform Suv39 h1 inhibitor | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O43463 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
SUV39H1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the SET domain of isoformn Suv39 h1 is essential for repressing gene expression of BZLF1, which acts as a master regulator of the transition from latency to the lytic replication cycle in latently Epstein-Barr virus-infected cells. Depletion of Suv39 h1 protein by siRNA results in increased expression of BZLF1 mRNA in B958 cells, and Suv39 h1 inhibitor chaetocin activates BZLF1 transcription | Homo sapiens |