Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
entorhinal cortex | - |
Rattus norvegicus | - |
hippocampus | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + histone H3(K9) | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G9a | - |
Rattus norvegicus |
G9a/G9a-like protein lysine dimethyltransferase complex | - |
Rattus norvegicus |
GLP | G9a-like protein | Rattus norvegicus |
histone H3 lysine 9 methyltransferase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of G9a/GLP in the entorhinal cortex (EC), but not in the hippocampus, enhances contextual fear conditioning relative to control animals. Downregulation of G9a/GLP activity in the EC enhances histone H3(K9) dimethylation in hippocampus area CA1, resulting in transcriptional silencing of the non-memory permissive gene COMT in the hippocampus | Rattus norvegicus |
physiological function | G9a/GLP activity is critical for hippocampus-dependent long-term potentiation initiated in the entorhinal cortex via the perforant pathway, but not the temporoammonic pathway. G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation | Rattus norvegicus |