Literature summary for 2.1.1.314 extracted from

Schaffrath, R.; Abdel-Fattah, W.; Klassen, R.; Stark, M.
The diphthamide modification pathway from Saccharomyces cerevisiae - revisited (2016), Mol. Microbiol., 94, 1213-1226 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2]	Saccharomyces cerevisiae	the enzyme is involved in the diphthamide modification pathway	4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2]	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2]	-	Saccharomyces cerevisiae	4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2]	-	?
4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2]	the enzyme is involved in the diphthamide modification pathway	Saccharomyces cerevisiae	4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2]	-	?

Synonyms

Synonyms	Comment	Organism
Dph5	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
malfunction	DPH5 gene overexpression causes growth defects in several dph mutant backgrounds. Higher-than-normal levels of Dph5 can inhibit the function of EF2, particularly when the translation factor is incompletely modified	Saccharomyces cerevisiae
physiological function	the enzyme is involved in the diphthamide modification pathway	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)