Application | Comment | Organism |
---|---|---|
medicine | targeting the enzyme is an effective strategy for treating HGPS | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-acetyl-S-farnesyl-L-cysteine | competitive inhibitor | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine | Mus musculus | - |
S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9EQK7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine | - |
Mus musculus | S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Icmt | - |
Mus musculus |
isoprenylcysteine carboxyl methyltransferase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | reduced enzyme activity causes prelamin A mislocalization within the nucleus and triggers prelamin A-dependent activation of AKT-mammalian target of rapamycin signaling, which abolishes the premature senescence of Zmpste24-deficient fibroblasts. Enzyme inhibition increases AKT-mammalian target of rapamycin signaling and proliferation and delays senescence in Hutchinson-Gilford progeria syndrome fibroblasts | Mus musculus |