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Literature summary for 1.8.4.12 extracted from
- Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo /631/45/612 /631/250 /38 /82 /82/80 article (2017), Sci. Rep., 7, 5119 .
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| selenium | selenoprotein | Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9JLC3 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| macrophage | highly expressed in immune-activated macrophages | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MSRB1 | - |
Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | lipopolysaccharide induces expression of MsrB1 | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| drug target | MsrB1-dependent reduction of oxidized methionine in proteins may be a regulatory event underlying immunity and inflammatory disease, and a novel target for clinical applications | Mus musculus |
| malfunction | genetic ablation of MsrB1 doesd not preclude LPS-induced intracellular signaling in macrophages, but results in attenuated induction of antiinflammatory cytokines, such as interleukin (IL)-10 and the IL-1 receptor antagonist | Mus musculus |
| physiological function | the enzyme (MsrB1) controls immune responses by promoting anti-inflammatory cytokine expression in macrophages | Mus musculus |
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