Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine-(R)-S-oxide + thioredoxin | Escherichia coli | the cofactor thioredoxin can be recycled in vivo by thionein due to its high content of cysteines, overview | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + thioredoxin | Homo sapiens | the cofactor thioredoxin can be recycled in vivo by thionein due to its high content of cysteines, overview | L-methionine + thioredoxin disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Homo sapiens | - |
isozyme MsrB2 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin | catalytic mechanism and the role of cofactor recycling in vivo | Escherichia coli | |
peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin | catalytic mechanism and the role of cofactor recycling in vivo | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine-(R)-S-oxide + DTT | - |
Escherichia coli | L-methionine + DTT disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + DTT | - |
Homo sapiens | L-methionine + DTT disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + thioredoxin | - |
Escherichia coli | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + thioredoxin | - |
Homo sapiens | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + thioredoxin | the cofactor thioredoxin can be recycled in vivo by thionein due to its high content of cysteines, overview | Escherichia coli | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + thioredoxin | the cofactor thioredoxin can be recycled in vivo by thionein due to its high content of cysteines, overview | Homo sapiens | L-methionine + thioredoxin disulfide + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MsrB | - |
Escherichia coli |
MsrB | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | can act as cofactor only in vitro showing a much higher activity than thioredoxin | Homo sapiens | |
dithiothreitol | can substitute for thioredoxin in vitro | Escherichia coli | |
thioredoxin | natural cofactor, the cofactor can be recycled in vivo by reduction via zinc-containing metallothionein, Zn-MT, after removal of the zinc ion due to its high content of cysteines, mechanism, overview | Homo sapiens | |
thioredoxin | preferred and natural cofactor, the cofactor can be recycled in vivo by reduction via zinc-containing metallothionein, Zn-MT, after removal of the zinc ion due to its high content of cysteines, mechanism, overview | Escherichia coli |