Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P00388 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
+ NADPH + H+ | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
1,4-dioxo-2-(trifluoromethyl)-1lambda5,4lambda5-quinoxaline + NADPH + H+ | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
1,4-dioxo-7-(trifluoromethoxy)-1lambda5,2,4lambda5-benzotriazin-3-amine + NADPH + H+ | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
1-oxo-1lambda5,2,4-benzotriazine + NADPH + H+ | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
3-amino-1,4-dioxo-1lambda5,4lambda5-quinoxaline-2-carbonitrile + NADPH + H+ | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
methyl (1,4-dioxo-1lambda5,2,4lambda5-benzotriazin-3-yl)carbamate + NADPH + H+ | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
N-(1,4-dioxo-1lambda5,2,4lambda5-benzotriazin-3-yl)-1,1,1-trifluoromethanesulfonamide + NADPH + H+ | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
N-(1,4-dioxo-1lambda5,2,4lambda5-benzotriazin-3-yl)acetamide + NADPH + H+ | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
N-(1,4-dioxo-1lambda5,2,4lambda5-benzotriazin-3-yl)methanesulfonamide + NADPH + H+ | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
N-(1-oxo-1lambda5,2,4-benzotriazin-3-yl)acetamide + NADPH + H+ | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
tirapazamine + NADPH + H+ | - |
Rattus norvegicus | 1,2,4-benzotriazin-3-amine + 1-oxo-1lambda5,2,4-benzotriazin-3-amine + NADP+ | - |
? |
General Information | Comment | Organism |
---|---|---|
drug target | the cytotoxicity of heteroaromatic N-oxides in murine hepatoma MH22a and human colon carcinoma HCT-116 cells increases with the geometric average of their reactivity towards NADPH:cytochrome P-450 reductase and and Plasmodium falciparum ferredoxin:NADP+ oxidoreductase, and with their reactivity towards rat NQO1 | Rattus norvegicus |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.7 | - |
N-(1,4-dioxo-1lambda5,2,4lambda5-benzotriazin-3-yl)methanesulfonamide | pH 7.4, 25°C | Rattus norvegicus | |
4.7 | - |
3-amino-1,4-dioxo-1lambda5,4lambda5-quinoxaline-2-carbonitrile | pH 7.4, 25°C | Rattus norvegicus | |
8.7 | - |
N-(1-oxo-1lambda5,2,4-benzotriazin-3-yl)acetamide | pH 7.4, 25°C | Rattus norvegicus | |
17 | - |
1-oxo-1lambda5,2,4-benzotriazine | pH 7.4, 25°C | Rattus norvegicus | |
25 | - |
N-(1,4-dioxo-1lambda5,2,4lambda5-benzotriazin-3-yl)-1,1,1-trifluoromethanesulfonamide | pH 7.4, 25°C | Rattus norvegicus | |
27 | - |
1,4-dioxo-2-(trifluoromethyl)-1lambda5,4lambda5-quinoxaline | pH 7.4, 25°C | Rattus norvegicus | |
46 | - |
1,4-dioxo-7-(trifluoromethoxy)-1lambda5,2,4lambda5-benzotriazin-3-amine | pH 7.4, 25°C | Rattus norvegicus | |
70 | - |
N-(1,4-dioxo-1lambda5,2,4lambda5-benzotriazin-3-yl)acetamide | pH 7.4, 25°C | Rattus norvegicus | |
80 | - |
methyl (1,4-dioxo-1lambda5,2,4lambda5-benzotriazin-3-yl)carbamate | pH 7.4, 25°C | Rattus norvegicus |