Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2',5'-ADP | increases internal electron transfer in dithionite reduced enzyme | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
W676H | rate of FAD-reduction is modestly affected, enzyme is reduced only to the two-electron level in rapid mixing experiments | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ferricytochrome P450 + NADPH | Homo sapiens | - |
2 ferrocytochrome P450 + NADP+ + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ferricytochrome c + NADH | 3-fold lower activity than with NADPH | Homo sapiens | 2 ferrocytochrome c + NAD+ + H+ | - |
? | |
2 ferricytochrome c + NADPH | - |
Homo sapiens | 2 ferrocytochrome c + NADP+ + H+ | - |
? | |
2 ferricytochrome P450 + NADPH | - |
Homo sapiens | 2 ferrocytochrome P450 + NADP+ + H+ | - |
? | |
ferricytochrome c + dithionite | - |
Homo sapiens | ferrocytochrome c + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NADPH-cytochrome P450 reductase | - |
Homo sapiens |
NADPH-ferrihemoprotein reductase | - |
Homo sapiens |
NADPH:ferrihemoprotein oxidoreductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | together with FMN, two binding sites | Homo sapiens | |
FMN | together with FAD | Homo sapiens | |
NADPH | - |
Homo sapiens |