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Literature summary for 1.5.3.5 extracted from

  • Decker, K.; Bleeg, H.
    Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans (1965), Biochim. Biophys. Acta, 105, 313-324.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
6-hydroxy-D-nicotine 50% inhibition at 0.18 mM Paenarthrobacter nicotinovorans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
6-hydroxy-L-nicotine
-
Paenarthrobacter nicotinovorans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-6-hydroxynicotine + H2O + O2 Paenarthrobacter nicotinovorans
-
1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Paenarthrobacter nicotinovorans
-
formerly Arthrobacter oxidans
-

Purification (Commentary)

Purification (Comment) Organism
partially Paenarthrobacter nicotinovorans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-6-hydroxynicotine + H2O + O2
-
Paenarthrobacter nicotinovorans 1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2
-
?
L-6-hydroxy-nor-nicotine + H2O + O2
-
Paenarthrobacter nicotinovorans 1-(6-hydroxypyrid-3-yl)-4-aminobutan-1-one + H2O2
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Paenarthrobacter nicotinovorans

Cofactor

Cofactor Comment Organism Structure
FAD
-
Paenarthrobacter nicotinovorans