Literature summary for 1.5.3.16 extracted from
Cervelli, M.; Polticelli, F.; Fiorucci, L.; Angelucci, E.; Federico, R.; Mariottini, P.
Inhibition of acetylpolyamine and spermine oxidases by the polyamine analogue chlorhexidine (2013), J. Enzyme Inhib. Med. Chem., 28, 463-467 .
No PubMed abstract available
Application
Application |
Comment |
Organism |
medicine |
the selective inhibitors of spermine oxidase represent an important tool for the development of novel anti-neoplastic drugs |
Mus musculus |
Cloned(Commentary)
Cloned (Comment) |
Organism |
expression in Escherichia coli |
Mus musculus |
Inhibitors
Inhibitors |
Comment |
Organism |
Structure |
Chlorhexidine |
poor inhibitor |
Mus musculus |
|
N,N'-bis(2,3-butadienyl)-1,4-butanediamine |
i.e. MDL 72527. Binding of the inhibitor to the enzyme takes place essentially only through a hydrophobic interaction with Trp62 side chain |
Mus musculus |
|
KM Value [mM]
KM Value [mM] |
KM Value Maximum [mM] |
Substrate |
Comment |
Organism |
Structure |
0.09 |
- |
spermine |
pH 8.3, 25°C |
Mus musculus |
|
Natural Substrates/ Products (Substrates)
Natural Substrates |
Organism |
Comment (Nat. Sub.) |
Natural Products |
Comment (Nat. Pro.) |
Rev. |
Reac. |
spermine + O2 + H2O |
Mus musculus |
the enzyme is involved in the catabolism of polyamines |
spermidine + 3-aminopropanal + H2O2 |
- |
? |
|
Organism
Organism |
UniProt |
Comment |
Textmining |
Mus musculus |
Q99K82 |
- |
- |
Substrates and Products (Substrate)
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
spermine + O2 + H2O |
- |
Mus musculus |
spermidine + 3-aminopropanal + H2O2 |
- |
? |
|
spermine + O2 + H2O |
the enzyme is involved in the catabolism of polyamines |
Mus musculus |
spermidine + 3-aminopropanal + H2O2 |
- |
? |
|
Synonyms
Synonyms |
Comment |
Organism |
SMO |
- |
Mus musculus |
Turnover Number [1/s]
Turnover Number Minimum [1/s] |
Turnover Number Maximum [1/s] |
Substrate |
Comment |
Organism |
Structure |
4.5 |
- |
spermine |
pH 8.3, 25°C |
Mus musculus |
|
Ki Value [mM]
Ki Value [mM] |
Ki Value maximum [mM] |
Inhibitor |
Comment |
Organism |
Structure |
0.00055 |
- |
Chlorhexidine |
pH 8.3, 25°C |
Mus musculus |
|
General Information
General Information |
Comment |
Organism |
metabolism |
the enzyme is involved in the catabolism of polyamines |
Mus musculus |