Activating Compound | Comment | Organism | Structure |
---|---|---|---|
HIV-1 Tat | Tat-induced SMO activation, involving the polyamine-sensitive subtype of the NMDA receptor, the activation is completely prevented by the NMDAR antagonist MK-801. Mechanism, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
spermine + O2 + H2O | Homo sapiens | - |
spermidine + 3-aminopropanal + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
neuroblastoma cell | - |
Homo sapiens | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
spermine + O2 + H2O | - |
Homo sapiens | spermidine + 3-aminopropanal + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SMO | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | ability of Tat to upregulate the activity of spermine oxidase, the polyamine catabolic enzyme that specifically oxidizes spermine, with the production of spermidine, H2O2, and 3-aminopropanal, through stimulation of the NMDA receptor, mechanism, overview | up |
General Information | Comment | Organism |
---|---|---|
physiological function | spermine oxidase plays a role as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity. HIV-1 Tat protein is found to induce reactive oxygen species production and to affect cell viability in SH-SY5Y cells, these effects being mediated by spermine oxidase. Pretreatment of cells with N-acetylcysteine, a scavenger of H2O2, and with MK-801 is able to completely inhibit reactive oxygen species formation and to restore cell viability, overview | Homo sapiens |