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Literature summary for 1.5.3.16 extracted from

  • Capone, C.; Cervelli, M.; Angelucci, E.; Colasanti, M.; Macone, A.; Mariottini, P.; Persichini, T.
    A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity (2013), Free Radic. Biol. Med., 63, 99-107.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
HIV-1 Tat Tat-induced SMO activation, involving the polyamine-sensitive subtype of the NMDA receptor, the activation is completely prevented by the NMDAR antagonist MK-801. Mechanism, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
spermine + O2 + H2O Homo sapiens
-
spermidine + 3-aminopropanal + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
neuroblastoma cell
-
Homo sapiens
-
SH-SY5Y cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
spermine + O2 + H2O
-
Homo sapiens spermidine + 3-aminopropanal + H2O2
-
?

Synonyms

Synonyms Comment Organism
SMO
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens ability of Tat to upregulate the activity of spermine oxidase, the polyamine catabolic enzyme that specifically oxidizes spermine, with the production of spermidine, H2O2, and 3-aminopropanal, through stimulation of the NMDA receptor, mechanism, overview up

General Information

General Information Comment Organism
physiological function spermine oxidase plays a role as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity. HIV-1 Tat protein is found to induce reactive oxygen species production and to affect cell viability in SH-SY5Y cells, these effects being mediated by spermine oxidase. Pretreatment of cells with N-acetylcysteine, a scavenger of H2O2, and with MK-801 is able to completely inhibit reactive oxygen species formation and to restore cell viability, overview Homo sapiens