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Literature summary for 1.5.3.13 extracted from

  • Moriya, S.S.; Miura, T.; Takao, K.; Sugita, Y.; Samejima, K.; Hiramatsu, K.; Kawakita, M.
    Development of irreversible inactivators of spermine oxidase and N1-acetylpolyamine oxidase (2014), Biol. Pharm. Bull., 37, 475-480 .
    View publication on PubMed
Search for more literature for 1.5.3.13

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK 293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibitory activity: N-(3-aminopropyl)-N-2-propynyl-1,4-butanediamine and N-[3-(2-propynylamino)propyl]-1,4-butanediamine Homo sapiens
N,N-di-2,3-butadienyl-1,4-butanediamine i.e. MDL 72527, strong inhibition Homo sapiens
N-(3-aminopropyl)-N-2-propenyl-1,4-butanediamine moderate inhibition Homo sapiens
N-(3-aminopropyl)-N-2,3-butadienyl-1,4-butanediamine strong inhibition Homo sapiens
N-[3-(2,3-butadienylamino)propyl]-1,4-butanediamine strong inhibition Homo sapiens
N-[3-(2-propenylamino) propyl]-1,4-butanediamine moderate inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N1-acetylspermidine + O2 + H2O Homo sapiens the enzyme is involved in polyamine catabolism. The enzyme is a constitutively expressed enzyme that catalyzes the oxidative cleavage of N1-acetylpolyamines to yield a less basic polyamine, 3-acetylamidopropanal, and hydrogen peroxide putrescine + 3-acetamidopropanal + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N1-acetylspermidine + O2 + H2O
-
 Homo sapiens putrescine + 3-acetamidopropanal + H2O2
-
 ?
N1-acetylspermidine + O2 + H2O the enzyme is involved in polyamine catabolism. The enzyme is a constitutively expressed enzyme that catalyzes the oxidative cleavage of N1-acetylpolyamines to yield a less basic polyamine, 3-acetylamidopropanal, and hydrogen peroxide Homo sapiens putrescine + 3-acetamidopropanal + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
APAO
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
 assay at Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme is involved in polyamine catabolism Homo sapiens