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Literature summary for 1.5.3.13 extracted from

  • Häkkinen, M.; Hyönen, M.; Auriola, S.; Casero Jr., R.; Vepsäläinen, J.; Khomutov, A.; Alhonen, L.; Keinänen, T.
    Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases (2010), Amino Acids, 38, 369-381.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics of APAO with diverse polyamine analogues and their predicted secondary metabolites, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N,N'-bis-(3-benzylaminopropyl)butane-1,4-diamine + O2 + H2O Homo sapiens
-
N1-(3-benzylaminopropyl)butane-1,4-diamine + N-(3-aminopropyl)-N'-(3-Benzylaminopropyl)butane-1,4-diamine + H2O2
-
?
N1,N12-diacetylspermine + O2 + H2O Homo sapiens
-
N1-acetylspermidine + 3-acetamidopropanal + H2O2
-
?
N1-acetylspermidine + O2 + H2O Homo sapiens
-
putrescine + 3-acetamidopropanal + H2O2
-
?
N1-acetylspermine + O2 + H2O Homo sapiens
-
spermidine + 3-acetamidopropanal + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
Homo sapiens
-
additional information APAO is constitutively expressed in various tissues Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information APAO is capable of metabolizing several N-alkylated polyamine derivatives, substrate specificity, overview. N1-(3-Ethylaminopropyl)butane-1,4-diamine trihydrochloride is a poor substrate Homo sapiens ?
-
?
N,N'-bis-(3-benzylaminopropyl)butane-1,4-diamine + O2 + H2O
-
Homo sapiens N1-(3-benzylaminopropyl)butane-1,4-diamine + N-(3-aminopropyl)-N'-(3-Benzylaminopropyl)butane-1,4-diamine + H2O2
-
?
N,N'-bis-(3-benzylaminopropyl)butane-1,4-diamine + O2 + H2O
-
Homo sapiens N1-(3-benzylaminopropyl)butane-1,4-diamine + H2O2 + ? main product ?
N,N'-bis-(3-ethylaminopropyl)butane-1,4-diamine + O2 + H2O minor N4-endo cleavage pathways resulting in formation of N1-ethylpropane-1,3-diamine Homo sapiens N1-(3-ethylaminopropyl)butane-1,4-diamine + H2O2 + ?
-
?
N-(3-benzylaminopropyl)-N'-(3-ethylaminopropyl)butane-1,4-diamine + O2 + H2O
-
Homo sapiens N1-(3-ethylaminopropyl)butane-1,4-diamine + H2O2 + ?
-
?
N1,N12-diacetylspermine + O2 + H2O
-
Homo sapiens N1-acetylspermidine + 3-acetamidopropanal + H2O2
-
?
N1-(3-benzylaminopropyl)butane-1,4-diamine + O2 + H2O
-
Homo sapiens spermidine + H2O2 + benzylalcohol
-
?
N1-acetylspermidine + O2 + H2O
-
Homo sapiens putrescine + 3-acetamidopropanal + H2O2
-
?
N1-acetylspermine + O2 + H2O
-
Homo sapiens spermidine + 3-acetamidopropanal + H2O2
-
?
N1-benzyl-propane-1,3-diamine + O2 + H2O
-
Homo sapiens propane-1,3-diamine + H2O2 + benzylalcohol
-
?

Synonyms

Synonyms Comment Organism
APAO
-
Homo sapiens

Temperature Optimum [Ā°C]

Temperature Optimum [Ā°C] Temperature Optimum Maximum [Ā°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens