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Literature summary for 1.5.1.7 extracted from
- Charakterisierung der Saccharopin-Dehydrogenase aus Phycomyces blakesleeanus (1979), Z. Pflanzenphysiol., 92, 23-31.
No PubMed abstract available
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.12 | - |
NADH | - |
Phycomyces blakesleeanus |  |
| 0.23 | - |
NADH | 2-oxoglutarate | Phycomyces blakesleeanus | |
| 1.34 | - |
L-lysine | - |
Phycomyces blakesleeanus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O | Phycomyces blakesleeanus | last step of alpha-aminoadipate pathway for lysine biosynthesis | L-lysine + 2-oxoglutarate + NADH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Phycomyces blakesleeanus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Phycomyces blakesleeanus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.09 | - |
crude extract | Phycomyces blakesleeanus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O | - |
Phycomyces blakesleeanus | L-lysine + 2-oxoglutarate + NADH | - |
r | |
| N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O | last step of alpha-aminoadipate pathway for lysine biosynthesis | Phycomyces blakesleeanus | L-lysine + 2-oxoglutarate + NADH | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 40 | - |
increase of activity from 20°C to 40°C | Phycomyces blakesleeanus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | 40 | increase of activity from 20°C to 40°C | Phycomyces blakesleeanus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
L-lysine + 2-oxoglutarate + NADH | Phycomyces blakesleeanus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.6 | 7.8 | half-maximal activities at pH 5.6 and 7.8 | Phycomyces blakesleeanus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Phycomyces blakesleeanus | |
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