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Literature summary for 1.5.1.7 extracted from

  • Schmidt, H.; Bode, R.; Birnbaum, D.
    Regulation of the lysine biosynthesis in Pichia guilliermondii (1989), Antonie van Leeuwenhoek, 56, 337-347.
    View publication on PubMed
Search for more literature for 1.5.1.7

Inhibitors

Inhibitors Comment Organism Structure
adenosine slight Meyerozyma guilliermondii
ADP
-
 Meyerozyma guilliermondii
AMP
-
 Meyerozyma guilliermondii
ATP
-
 Meyerozyma guilliermondii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.13
-
 NADH
-
 Meyerozyma guilliermondii
0.5
-
 2-oxoglutarate
-
 Meyerozyma guilliermondii
0.9
-
 L-lysine
-
 Meyerozyma guilliermondii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
 gel filtration with Sephadex G-200 Meyerozyma guilliermondii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Meyerozyma guilliermondii involved in lysine biosynthesis L-lysine + 2-oxoglutarate + NADH
-
 ?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Meyerozyma guilliermondii last step of alpha-aminoadipate pathway for lysine biosynthesis L-lysine + 2-oxoglutarate + NADH
-
 ?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Meyerozyma guilliermondii H17 involved in lysine biosynthesis L-lysine + 2-oxoglutarate + NADH
-
 ?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Meyerozyma guilliermondii H17 last step of alpha-aminoadipate pathway for lysine biosynthesis L-lysine + 2-oxoglutarate + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Meyerozyma guilliermondii
-
 yeast
-
Meyerozyma guilliermondii H17
-
 yeast
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00018
-
-
 Meyerozyma guilliermondii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine biosynthesis Meyerozyma guilliermondii L-lysine + 2-oxoglutarate + NADH
-
 ?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O last step of alpha-aminoadipate pathway for lysine biosynthesis Meyerozyma guilliermondii L-lysine + 2-oxoglutarate + NADH
-
 ?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine biosynthesis Meyerozyma guilliermondii H17 L-lysine + 2-oxoglutarate + NADH
-
 ?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O last step of alpha-aminoadipate pathway for lysine biosynthesis Meyerozyma guilliermondii H17 L-lysine + 2-oxoglutarate + NADH
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1
-
 saccharopine + NAD+ + H2O Meyerozyma guilliermondii

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Meyerozyma guilliermondii