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Literature summary for 1.5.1.7 extracted from

  • Schmidt, H.; Bode, R.; Lindner, M.; Birnbaum, D.
    Lysine biosynthesis in the yeast Candida maltosa: properties of some enzymes and regulation of the biosynthetic pathway (1985), J. Basic Microbiol., 25, 675-681.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
amino acids hydrophobic amino acids with 5 or 6 carbon atoms; hydroxylic amino acids Candida maltosa
L-isoleucine
-
Candida maltosa
L-leucine
-
Candida maltosa
L-norleucine
-
Candida maltosa
L-ornithine
-
Candida maltosa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.23
-
NADH
-
Candida maltosa
0.66
-
2-oxoglutarate
-
Candida maltosa
1.6
-
L-lysine
-
Candida maltosa

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ 4% of control activity at 1 mM Candida maltosa
Hg2+ complete inhibition at 1 mM Candida maltosa
Mn2+ 46% of control activity at 1 mM Candida maltosa
Sn2+ 11% of control activity at 1 mM Candida maltosa
Zn2+ 66% of control activity at 1 mM Candida maltosa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
gel filtration Candida maltosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Candida maltosa involved in lysine biosynthesis L-lysine + 2-oxoglutarate + NADH
-
?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Candida maltosa last step of alpha-aminoadipate pathway for lysine biosynthesis L-lysine + 2-oxoglutarate + NADH
-
?

Organism

Organism UniProt Comment Textmining
Candida maltosa
-
-
-
Candida maltosa L4
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O i.e. saccharopine Candida maltosa L-lysine + 2-oxoglutarate + NADH
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine biosynthesis Candida maltosa L-lysine + 2-oxoglutarate + NADH
-
?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O last step of alpha-aminoadipate pathway for lysine biosynthesis Candida maltosa L-lysine + 2-oxoglutarate + NADH
-
?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O i.e. saccharopine Candida maltosa L4 L-lysine + 2-oxoglutarate + NADH
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
L-lysine + 2-oxoglutarate + NADH Candida maltosa

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Candida maltosa