Application | Comment | Organism |
---|---|---|
medicine | formic acidemia: toxicity of methanol in humans is correlated with formate accumulation as a result of low rates of formate oxidation, which is in vivo dependent on enzyme activity and on hepatic tetrahydrofolate levels | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cloning and sequencing of the cDNA encoding FDH from fetal liver | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
98700 | - |
x * 98700, protein with 902 amino acids, calculated from cDNA | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + NADP+ + H2O | Homo sapiens | enzyme is an important factor in regulation of formate oxidation and is related with methanol poisoning | tetrahydrofolate + CO2 + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | protein with conserved potential N-glycosylation sites, protein kinase phosphorylation sites, and N-myristoylation sites, post-translational modification may be important for the function | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | mainly expressed in | Homo sapiens | - |
liver | mainly expressed in fetal liver | Homo sapiens | - |
muscle | mainly expressed in skeletal muscle | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + NADP+ + H2O | Cys-707 is involved in enzyme activity | Homo sapiens | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
10-formyltetrahydrofolate + NADP+ + H2O | enzyme is an important factor in regulation of formate oxidation and is related with methanol poisoning | Homo sapiens | tetrahydrofolate + CO2 + NADPH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 98700, protein with 902 amino acids, calculated from cDNA | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
10-formyltetrahydrofolate | 10-formyltetrahydrofolate | Homo sapiens | |
NADP+ | - |
Homo sapiens | |
tetrahydrofolate | - |
Homo sapiens |