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Literature summary for 1.5.1.6 extracted from

  • Hong, M.; Lee, Y.; Kim, J.W.; Lim, J.S.; Chang, S.Y.; Lee, K.S.; Paik, S.G.; Choe, I.S.
    Isolation and characterization of cDNA clone for human liver 10-formyltetrahydrofolate dehydrogenase (1999), Biochem. Mol. Biol. Int., 47, 407-415.
    View publication on PubMed

Application

Application Comment Organism
medicine formic acidemia: toxicity of methanol in humans is correlated with formate accumulation as a result of low rates of formate oxidation, which is in vivo dependent on enzyme activity and on hepatic tetrahydrofolate levels Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
cloning and sequencing of the cDNA encoding FDH from fetal liver Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
98700
-
x * 98700, protein with 902 amino acids, calculated from cDNA Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + NADP+ + H2O Homo sapiens enzyme is an important factor in regulation of formate oxidation and is related with methanol poisoning tetrahydrofolate + CO2 + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information protein with conserved potential N-glycosylation sites, protein kinase phosphorylation sites, and N-myristoylation sites, post-translational modification may be important for the function Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney mainly expressed in Homo sapiens
-
liver mainly expressed in fetal liver Homo sapiens
-
muscle mainly expressed in skeletal muscle Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate + NADP+ + H2O Cys-707 is involved in enzyme activity Homo sapiens tetrahydrofolate + CO2 + NADPH + H+
-
?
10-formyltetrahydrofolate + NADP+ + H2O enzyme is an important factor in regulation of formate oxidation and is related with methanol poisoning Homo sapiens tetrahydrofolate + CO2 + NADPH + H+
-
?

Subunits

Subunits Comment Organism
? x * 98700, protein with 902 amino acids, calculated from cDNA Homo sapiens

Cofactor

Cofactor Comment Organism Structure
10-formyltetrahydrofolate 10-formyltetrahydrofolate Homo sapiens
NADP+
-
Homo sapiens
tetrahydrofolate
-
Homo sapiens