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Literature summary for 1.4.3.5 extracted from

  • Mascolo, E.; Amoroso, N.; Saggio, I.; Merigliano, C.; Verni, F.
    Pyridoxine/pyridoxamine 5-phosphate oxidase (Sgll/PNPO) is important for DNA integrity and glucose homeostasis maintenance in Drosophila (2020), J. Cell. Physiol., 235, 504-512 .
    View publication on PubMed
Search for more literature for 1.4.3.5

Inhibitors

Inhibitors Comment Organism Structure
1-(propan-2-yl)-6-[2-[4-(propan-2-yl)phenoxy]ethoxy]-1,3-dihydro-2H-benzimidazol-2-one
-
 Drosophila melanogaster
1-ethyl-6-[2-(3-fluorophenoxy)ethoxy]-1,3-dihydro-2H-benzimidazol-2-one
-
 Drosophila melanogaster
1-ethyl-6-[2-[4-(propan-2-yl)phenoxy]ethoxy]-1,3-dihydro-2H-benzimidazol-2-one
-
 Drosophila melanogaster
1-ethyl-6-[[4-(trifluoromethyl)phenyl]methoxy]-1,3-dihydro-2H-benzimidazol-2-one
-
 Drosophila melanogaster
1-methyl-6-(3-phenylpropoxy)-1,3-dihydro-2H-benzimidazol-2-one
-
 Drosophila melanogaster
5-[(3,4-dichlorophenyl)methoxy]-1,3-dihydro-2H-indol-2-one
-
 Drosophila melanogaster
5-[(3,4-dichlorophenyl)methoxy]-1H-indole-2,3-dione
-
 Drosophila melanogaster
5-[(3,4-dichlorophenyl)methoxy]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one
-
 Drosophila melanogaster
5-[(3-chlorophenyl)methoxy]-1H-indole-2,3-dione
-
 Drosophila melanogaster
5-[(3-chlorophenyl)methoxy]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one
-
 Drosophila melanogaster
5-[(3-fluorophenyl)methoxy]-3-(propan-2-yl)-1,3-dihydro-2H-indol-2-one
-
 Drosophila melanogaster
5-[(4-fluorophenyl)methoxy]-1,3-dihydro-2H-indol-2-one
-
 Drosophila melanogaster
5-[(4-fluorophenyl)methoxy]-1H-indole-2,3-dione
-
 Drosophila melanogaster
5-[2-(4-fluorophenyl)ethoxy]-1,3-dihydro-2H-indol-2-one
-
 Drosophila melanogaster
5-[2-(4-fluorophenyl)ethoxy]-1H-indole-2,3-dione
-
 Drosophila melanogaster
6-[(3,4-dichlorophenyl)methoxy]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one
-
 Drosophila melanogaster
6-[(3-chlorophenyl)methoxy]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one
-
 Drosophila melanogaster
6-[(4-chlorophenyl)methoxy]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one
-
 Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9VHZ5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyridoxamine 5'-phosphate + H2O + O2
-
 Drosophila melanogaster pyridoxal 5'-phosphate + NH3 + H2O2
-
 ?
pyridoxine 5'-phosphate + O2
-
 Drosophila melanogaster pyridoxal 5'-phosphate + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
pyridoxine/pyridoxamine 5'-phosphate oxidase
-
 Drosophila melanogaster
sgll
-
 Drosophila melanogaster
Sgll/PNPO
-
 Drosophila melanogaster

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.003
-
 pH and temperature not specified in the publication Drosophila melanogaster 5-[(3,4-dichlorophenyl)methoxy]-1H-indole-2,3-dione
0.046
-
 pH and temperature not specified in the publication Drosophila melanogaster 5-[(3-chlorophenyl)methoxy]-1H-indole-2,3-dione
0.073
-
 pH and temperature not specified in the publication Drosophila melanogaster 5-[(4-fluorophenyl)methoxy]-1H-indole-2,3-dione
0.102
-
 pH and temperature not specified in the publication Drosophila melanogaster 5-[2-(4-fluorophenyl)ethoxy]-1H-indole-2,3-dione
7.68
-
 pH and temperature not specified in the publication Drosophila melanogaster 6-[(3,4-dichlorophenyl)methoxy]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one
17.17
-
 pH and temperature not specified in the publication Drosophila melanogaster 5-[(3,4-dichlorophenyl)methoxy]-1,3-dihydro-2H-indol-2-one
24.94
-
 pH and temperature not specified in the publication Drosophila melanogaster 5-[(4-fluorophenyl)methoxy]-1,3-dihydro-2H-indol-2-one
34.3
-
 pH and temperature not specified in the publication Drosophila melanogaster 6-[(3-chlorophenyl)methoxy]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one
56.4
-
 pH and temperature not specified in the publication Drosophila melanogaster 6-[(4-chlorophenyl)methoxy]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one
59.63
-
 pH and temperature not specified in the publication Drosophila melanogaster 1-methyl-6-(3-phenylpropoxy)-1,3-dihydro-2H-benzimidazol-2-one
66.72
-
 pH and temperature not specified in the publication Drosophila melanogaster 1-(propan-2-yl)-6-[2-[4-(propan-2-yl)phenoxy]ethoxy]-1,3-dihydro-2H-benzimidazol-2-one
116.8
-
 pH and temperature not specified in the publication Drosophila melanogaster 5-[(3,4-dichlorophenyl)methoxy]-1H-indole-2,3-dione
132.4
-
 pH and temperature not specified in the publication Drosophila melanogaster 5-[(3,4-dichlorophenyl)methoxy]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one
184.1
-
 pH and temperature not specified in the publication Drosophila melanogaster 1-ethyl-6-[[4-(trifluoromethyl)phenyl]methoxy]-1,3-dihydro-2H-benzimidazol-2-one
190.1
-
 pH and temperature not specified in the publication Drosophila melanogaster 5-[2-(4-fluorophenyl)ethoxy]-1,3-dihydro-2H-indol-2-one
190.5
-
 pH and temperature not specified in the publication Drosophila melanogaster 1-ethyl-6-[2-(3-fluorophenoxy)ethoxy]-1,3-dihydro-2H-benzimidazol-2-one
234.6
-
 pH and temperature not specified in the publication Drosophila melanogaster 5-[(4-fluorophenyl)methoxy]-1H-indole-2,3-dione
277.6
-
 pH and temperature not specified in the publication Drosophila melanogaster 1-ethyl-6-[2-[4-(propan-2-yl)phenoxy]ethoxy]-1,3-dihydro-2H-benzimidazol-2-one
279
-
 pH and temperature not specified in the publication Drosophila melanogaster 5-[(3-chlorophenyl)methoxy]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one
310.9
-
 pH and temperature not specified in the publication Drosophila melanogaster 5-[(3-chlorophenyl)methoxy]-1H-indole-2,3-dione
396.6
-
 pH and temperature not specified in the publication Drosophila melanogaster 5-[(3-fluorophenyl)methoxy]-3-(propan-2-yl)-1,3-dihydro-2H-indol-2-one

General Information

General Information Comment Organism
metabolism the enzyme is important for DNA integrity and glucose homeostasis maintenance in Drosophila Drosophila melanogaster