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Literature summary for 1.4.3.4 extracted from

  • Carroll, R.T.; Dluzen, D.E.; Stinnett, H.; Awale, P.S.; Funk, M.O.; Geldenhuys, W.J.
    Structure-activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B (2011), Bioorg. Med. Chem. Lett., 21, 4798-4803.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2E)-2-(2,4-dioxo-1,3-thiazolidin-5-ylidene)-N-(3-hydroxyphenyl)ethanamide
-
Homo sapiens
(2E)-2-(2,4-dioxo-1,3-thiazolidin-5-ylidene)-N-phenylethanamide
-
Homo sapiens
(5E)-3-(2-aminoethyl)-5-(2-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
(5E)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
(5E)-3-(2-aminoethyl)-5-[4-(dimethylamino)benzylidene]-1,3-thiazolidine-2,4-dione
-
Homo sapiens
(5E)-5-(3-bromobenzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
(5E)-5-(4-chlorobenzylidene)-3-methyl-2-thioxo-1,3-thiazolidin-4-one
-
Homo sapiens
(5E)-5-(4-hydroxy-2,5-dimethoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
-
Homo sapiens
(5E)-5-(4-hydroxy-3-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
-
Homo sapiens
(5E)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
(5E)-5-benzylidene-2-imino-1,3-thiazolidin-4-one
-
Homo sapiens
(5E)-5-benzylidene-3-methyl-2-thioxo-1,3-thiazolidin-4-one
-
Homo sapiens
(5E)-5-[(3,5-dibromo-4-hydroxycyclohexa-1,4-dien-1-yl)methylidene]-1,3-thiazolidine-2,4-dione
-
Homo sapiens
3-(4-hydroxyphenyl)-2-(4-oxo-2-thioxo-1,3-thiazolidin-3-yl)propanoic acid
-
Homo sapiens
3-[(5E)-5-benzylidene-2,4-dioxo-1,3-thiazolidin-3-yl]propanenitrile
-
Homo sapiens
3-[(5E)-5-benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
Homo sapiens
4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)amino]benzoic acid
-
Homo sapiens
5-(3,5-di-tert-butyl-4-hydroxybenzyl)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(4-hydroxy-3,5-dimethylbenzyl)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(4-hydroxybenzyl)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-[(4-acetylcyclohexa-1,4-dien-1-yl)methyl]-1,3-thiazolidine-2,4-dione ammoniate (1:1)
-
Homo sapiens
5-[(4-acetylcyclohexa-1,4-dien-1-yl)methyl]-2-imino-1,3-thiazolidin-4-one
-
Homo sapiens
ciglitazone
-
Homo sapiens
rosiglitazone
-
Homo sapiens
troglitazone
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
kynuramine + H2O + O2 Homo sapiens
-
3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kynuramine + H2O + O2
-
Homo sapiens 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
MAO-B
-
Homo sapiens
monoamine oxidase B
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000082
-
pH and temperature not specified in the publication Homo sapiens (5E)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)-1,3-thiazolidine-2,4-dione
0.000195
-
pH and temperature not specified in the publication Homo sapiens (5E)-3-(2-aminoethyl)-5-[4-(dimethylamino)benzylidene]-1,3-thiazolidine-2,4-dione
0.0008
-
pH and temperature not specified in the publication Homo sapiens 5-[(4-acetylcyclohexa-1,4-dien-1-yl)methyl]-1,3-thiazolidine-2,4-dione ammoniate (1:1)
0.00102
-
pH and temperature not specified in the publication Homo sapiens (5E)-5-[(3,5-dibromo-4-hydroxycyclohexa-1,4-dien-1-yl)methylidene]-1,3-thiazolidine-2,4-dione
0.00225
-
pH and temperature not specified in the publication Homo sapiens 5-(4-hydroxybenzyl)-1,3-thiazolidine-2,4-dione
0.00229
-
pH and temperature not specified in the publication Homo sapiens 3-[(5E)-5-benzylidene-2,4-dioxo-1,3-thiazolidin-3-yl]propanenitrile
0.00238
-
pH and temperature not specified in the publication Homo sapiens 5-(3,5-di-tert-butyl-4-hydroxybenzyl)-1,3-thiazolidine-2,4-dione
0.00249
-
pH and temperature not specified in the publication Homo sapiens (5E)-5-(4-hydroxy-3-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
0.00607
-
pH and temperature not specified in the publication Homo sapiens (5E)-5-(3-bromobenzylidene)-1,3-thiazolidine-2,4-dione
0.01051
-
pH and temperature not specified in the publication Homo sapiens (5E)-5-benzylidene-3-methyl-2-thioxo-1,3-thiazolidin-4-one
0.011
-
pH and temperature not specified in the publication Homo sapiens (2E)-2-(2,4-dioxo-1,3-thiazolidin-5-ylidene)-N-(3-hydroxyphenyl)ethanamide
0.013
-
pH and temperature not specified in the publication Homo sapiens (5E)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
0.01606
-
pH and temperature not specified in the publication Homo sapiens 5-(4-hydroxy-3,5-dimethylbenzyl)-1,3-thiazolidine-2,4-dione
0.02 2 pH and temperature not specified in the publication Homo sapiens (2E)-2-(2,4-dioxo-1,3-thiazolidin-5-ylidene)-N-phenylethanamide
0.02405
-
pH and temperature not specified in the publication Homo sapiens (5E)-5-benzylidene-2-imino-1,3-thiazolidin-4-one
0.027
-
pH and temperature not specified in the publication Homo sapiens (5E)-3-(2-aminoethyl)-5-(2-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
0.03165
-
pH and temperature not specified in the publication Homo sapiens (5E)-5-(4-hydroxy-2,5-dimethoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
0.03648
-
pH and temperature not specified in the publication Homo sapiens (5E)-5-(4-chlorobenzylidene)-3-methyl-2-thioxo-1,3-thiazolidin-4-one
0.056
-
pH and temperature not specified in the publication Homo sapiens 4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)amino]benzoic acid
0.2729
-
pH and temperature not specified in the publication Homo sapiens 3-(4-hydroxyphenyl)-2-(4-oxo-2-thioxo-1,3-thiazolidin-3-yl)propanoic acid
0.3089
-
pH and temperature not specified in the publication Homo sapiens 5-[(4-acetylcyclohexa-1,4-dien-1-yl)methyl]-2-imino-1,3-thiazolidin-4-one
0.6043
-
pH and temperature not specified in the publication Homo sapiens 3-[(5E)-5-benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid