Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-oxo-4H-chromene-3-carboxylic acid | specific for MAO-B | Homo sapiens | |
Clorgyline | inhibits both MAO-A and MAO-B | Homo sapiens | |
Iproniazide | inhibits both MAO-A and MAO-B | Homo sapiens | |
moclobemide | specific for MAO-A | Homo sapiens | |
additional information | evaluation of chromone carboxylic acids as enzyme inhibitors, only chromone-3-carboxylic acid is a potent MAO-B inhibitor, with a high degree of selectivity for MAO-B compared to MAO-A, no inhibition by 4-oxo-4H-chromene-2-carboxylic acid at 0.1 mM, molecular docking, overview | Homo sapiens | |
R-(-)-deprenyl | inhibits both MAO-A and MAO-B | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-phenylethylamine + H2O + O2 | Homo sapiens | - |
? | - |
? | |
benzylamine + H2O + O2 | Homo sapiens | - |
benzaldehyde + NH3 + H2O2 | - |
? | |
dopamine + H2O + O2 | Homo sapiens | - |
? | - |
? | |
norepinephrine + H2O + O2 | Homo sapiens | - |
? | - |
? | |
serotonin + H2O + O2 | Homo sapiens | substrate of MAO-A | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
tyramine + H2O + O2 | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-phenylethylamine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
benzylamine + H2O + O2 | - |
Homo sapiens | benzaldehyde + NH3 + H2O2 | - |
? | |
dopamine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
norepinephrine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
serotonin + H2O + O2 | substrate of MAO-A | Homo sapiens | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
tyramine + H2O + O2 | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Homo sapiens |
MAO-B | - |
Homo sapiens |
monoamine oxidases A | - |
Homo sapiens |
monoamine oxidases B | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000052 | - |
MAO-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | Clorgyline | |
0.000017 | - |
MAO-B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | R-(-)-deprenyl | |
0.00656 | - |
MAO-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | Iproniazide | |
0.00754 | - |
MAO-B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | Iproniazide | |
0.0634 | - |
MAO-B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | Clorgyline | |
0.0687 | - |
MAO-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | R-(-)-deprenyl | |
0.3614 | - |
MAO-A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | moclobemide |