Cloned (Comment) | Organism |
---|---|
gene Y69Ap, expression of DAO in Escherichia coli | Caenorhabditis elegans |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics in comparison to the human enzyme, overview | Caenorhabditis elegans | |
1.01 | - |
D-Arg | pH 8.3, 37°C, recombinant DAO | Caenorhabditis elegans | |
2.72 | - |
D-Phe | pH 8.3, 37°C, recombinant DAO | Caenorhabditis elegans | |
2.89 | - |
D-His | pH 8.3, 37°C, recombinant DAO | Caenorhabditis elegans | |
6.89 | - |
D-Ala | pH 8.3, 37°C, recombinant DAO | Caenorhabditis elegans | |
20 | - |
D-Ser | pH 8.3, 37°C, recombinant DAO | Caenorhabditis elegans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Caenorhabditis elegans | 5777 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
36117 | - |
x * 36117, sequence calculation | Caenorhabditis elegans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Ala + H2O + O2 | Caenorhabditis elegans | - |
pyruvate + NH3 + H2O2 | - |
? | |
D-Arg + H2O + O2 | Caenorhabditis elegans | - |
5-guanidino-2-oxopentanoic acid + NH3 + H2O2 | - |
? | |
D-His + H2O + O2 | Caenorhabditis elegans | - |
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2 | - |
? | |
D-Phe + H2O + O2 | Caenorhabditis elegans | - |
phenylpyruvate + NH3 + H2O2 | - |
? | |
D-Ser + H2O + O2 | Caenorhabditis elegans | - |
2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
gene Y69Ap | - |
Purification (Comment) | Organism |
---|---|
recombinant DAO from Escherichia coli to homogeneity | Caenorhabditis elegans |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Ala + H2O + O2 | - |
Caenorhabditis elegans | pyruvate + NH3 + H2O2 | - |
? | |
D-Arg + H2O + O2 | - |
Caenorhabditis elegans | 5-guanidino-2-oxopentanoic acid + NH3 + H2O2 | - |
? | |
D-His + H2O + O2 | - |
Caenorhabditis elegans | 3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2 | - |
? | |
D-Phe + H2O + O2 | - |
Caenorhabditis elegans | phenylpyruvate + NH3 + H2O2 | - |
? | |
D-Ser + H2O + O2 | - |
Caenorhabditis elegans | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
additional information | DAO shows no activity with D-Asp, N-methyl-D-Asp, and D-Glu | Caenorhabditis elegans | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 36117, sequence calculation | Caenorhabditis elegans |
Synonyms | Comment | Organism |
---|---|---|
DAAO | - |
Caenorhabditis elegans |
DAO | - |
Caenorhabditis elegans |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Caenorhabditis elegans |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.51 | - |
D-Ser | pH 8.3, 37°C, recombinant DAO | Caenorhabditis elegans | |
1.51 | - |
D-His | pH 8.3, 37°C, recombinant DAO | Caenorhabditis elegans | |
2.83 | - |
D-Arg | pH 8.3, 37°C, recombinant DAO | Caenorhabditis elegans | |
14.9 | - |
D-Ala | pH 8.3, 37°C, recombinant DAO | Caenorhabditis elegans | |
25.1 | - |
D-Phe | pH 8.3, 37°C, recombinant DAO | Caenorhabditis elegans |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.3 | - |
assay at | Caenorhabditis elegans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
physiological function | D-amino acid oxidase is a FAD-containing flavoprotein that catalyzes the oxidative deamination of D-amino acids with O2 to generate the corresponding 2-oxo acids, along with H2O2 and NH3 | Caenorhabditis elegans |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
75 | - |
D-Ser | pH 8.3, 37°C, recombinant DAO | Caenorhabditis elegans | |
521 | - |
D-His | pH 8.3, 37°C, recombinant DAO | Caenorhabditis elegans | |
2165 | - |
D-Ala | pH 8.3, 37°C, recombinant DAO | Caenorhabditis elegans | |
2802 | - |
D-Arg | pH 8.3, 37°C, recombinant DAO | Caenorhabditis elegans | |
9215 | - |
D-Phe | pH 8.3, 37°C, recombinant DAO | Caenorhabditis elegans |