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Literature summary for 1.4.3.3 extracted from

  • Katane, M.; Saitoh, Y.; Seida, Y.; Sekine, M.; Furuchi, T.; Homma, H.
    Comparative characterization of three D-aspartate oxidases and one D-amino acid oxidase from Caenorhabditis elegans (2010), Chem. Biodivers., 7, 1424-1434.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene Y69Ap, expression of DAO in Escherichia coli Caenorhabditis elegans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics in comparison to the human enzyme, overview Caenorhabditis elegans
1.01
-
D-Arg pH 8.3, 37°C, recombinant DAO Caenorhabditis elegans
2.72
-
D-Phe pH 8.3, 37°C, recombinant DAO Caenorhabditis elegans
2.89
-
D-His pH 8.3, 37°C, recombinant DAO Caenorhabditis elegans
6.89
-
D-Ala pH 8.3, 37°C, recombinant DAO Caenorhabditis elegans
20
-
D-Ser pH 8.3, 37°C, recombinant DAO Caenorhabditis elegans

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
Caenorhabditis elegans 5777
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36117
-
x * 36117, sequence calculation Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-Ala + H2O + O2 Caenorhabditis elegans
-
pyruvate + NH3 + H2O2
-
?
D-Arg + H2O + O2 Caenorhabditis elegans
-
5-guanidino-2-oxopentanoic acid + NH3 + H2O2
-
?
D-His + H2O + O2 Caenorhabditis elegans
-
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
?
D-Phe + H2O + O2 Caenorhabditis elegans
-
phenylpyruvate + NH3 + H2O2
-
?
D-Ser + H2O + O2 Caenorhabditis elegans
-
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
gene Y69Ap
-

Purification (Commentary)

Purification (Comment) Organism
recombinant DAO from Escherichia coli to homogeneity Caenorhabditis elegans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Ala + H2O + O2
-
Caenorhabditis elegans pyruvate + NH3 + H2O2
-
?
D-Arg + H2O + O2
-
Caenorhabditis elegans 5-guanidino-2-oxopentanoic acid + NH3 + H2O2
-
?
D-His + H2O + O2
-
Caenorhabditis elegans 3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
?
D-Phe + H2O + O2
-
Caenorhabditis elegans phenylpyruvate + NH3 + H2O2
-
?
D-Ser + H2O + O2
-
Caenorhabditis elegans 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
?
additional information DAO shows no activity with D-Asp, N-methyl-D-Asp, and D-Glu Caenorhabditis elegans ?
-
?

Subunits

Subunits Comment Organism
? x * 36117, sequence calculation Caenorhabditis elegans

Synonyms

Synonyms Comment Organism
DAAO
-
Caenorhabditis elegans
DAO
-
Caenorhabditis elegans

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Caenorhabditis elegans

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.51
-
D-Ser pH 8.3, 37°C, recombinant DAO Caenorhabditis elegans
1.51
-
D-His pH 8.3, 37°C, recombinant DAO Caenorhabditis elegans
2.83
-
D-Arg pH 8.3, 37°C, recombinant DAO Caenorhabditis elegans
14.9
-
D-Ala pH 8.3, 37°C, recombinant DAO Caenorhabditis elegans
25.1
-
D-Phe pH 8.3, 37°C, recombinant DAO Caenorhabditis elegans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.3
-
assay at Caenorhabditis elegans

Cofactor

Cofactor Comment Organism Structure
FAD
-
Caenorhabditis elegans

General Information

General Information Comment Organism
physiological function D-amino acid oxidase is a FAD-containing flavoprotein that catalyzes the oxidative deamination of D-amino acids with O2 to generate the corresponding 2-oxo acids, along with H2O2 and NH3 Caenorhabditis elegans

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
75
-
D-Ser pH 8.3, 37°C, recombinant DAO Caenorhabditis elegans
521
-
D-His pH 8.3, 37°C, recombinant DAO Caenorhabditis elegans
2165
-
D-Ala pH 8.3, 37°C, recombinant DAO Caenorhabditis elegans
2802
-
D-Arg pH 8.3, 37°C, recombinant DAO Caenorhabditis elegans
9215
-
D-Phe pH 8.3, 37°C, recombinant DAO Caenorhabditis elegans