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Literature summary for 1.4.3.3 extracted from

  • Abou El-Magd, R.; Park, H.; Kawazoe, T.; Iwana, S.; Ono, K.; Chung, S.; Miyano, M.; Yorita, K.; Sakai, T.; Fukui, K.
    The effect of risperidone on D-amino acid oxidase activity as a hypothesis for a novel mechanism of action in the treatment of schizophrenia (2009), J. Psychopharmacol. (Oxford), 2009, 1-13.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme is a target in schizophrenia treatment Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression in rat C6 cells Mus musculus
recombinant expression of the enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
benzoate
-
Homo sapiens
benzoate
-
Mus musculus
benzoate
-
Sus scrofa
risperidone
-
Homo sapiens
risperidone
-
Mus musculus
risperidone
-
Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
Mus musculus 5777
-
peroxisome
-
Homo sapiens 5777
-
peroxisome
-
Sus scrofa 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-alanine + H2O + O2 Mus musculus
-
pyruvate + NH3 + H2O2
-
?
D-alanine + H2O + O2 Homo sapiens
-
pyruvate + NH3 + H2O2
-
?
D-alanine + H2O + O2 Sus scrofa
-
pyruvate + NH3 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Sus scrofa
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
flavoprotein
-
Mus musculus
flavoprotein
-
Homo sapiens
flavoprotein
-
Sus scrofa

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme by ammonium sulfate fractionation, anion exchange chromatography, and dialysis Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
brain
-
Sus scrofa
-
epithelial cell
-
Sus scrofa
-
kidney
-
Mus musculus
-
kidney
-
Homo sapiens
-
kidney
-
Sus scrofa
-
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
liver
-
Sus scrofa
-
LLC-PK1 cell a renal epithelial cell line Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-alanine + H2O + O2
-
Mus musculus pyruvate + NH3 + H2O2
-
?
D-alanine + H2O + O2
-
Homo sapiens pyruvate + NH3 + H2O2
-
?
D-alanine + H2O + O2
-
Sus scrofa pyruvate + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
DAO
-
Mus musculus
DAO
-
Homo sapiens
DAO
-
Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Mus musculus
25
-
assay at Homo sapiens
25
-
assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.3
-
assay at Mus musculus
8.3
-
assay at Homo sapiens
8.3
-
assay at Sus scrofa

Cofactor

Cofactor Comment Organism Structure
FAD flavoenzyme Mus musculus
FAD flavoenzyme Homo sapiens
FAD flavoenzyme Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics with risperidone, in vivo inhibition of cellular DAO activity in LLC-PK1 cells and cytotoxicity, overview Homo sapiens
additional information
-
additional information inhibition kinetics with risperidone, in vivo inhibition of cellular DAO activity in LLC-PK1 cells and cytotoxicity, overview Sus scrofa

General Information

General Information Comment Organism
physiological function the enzyme is involved in the development of schizophrenia, mechanism, overview Homo sapiens