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Literature summary for 1.4.3.22 extracted from

  • Bieganski, T.; Kusche, J.; Lorenz, W.; Hesterberg, R.; Stahlknecht, C.D.; Feussner, K.D.
    Distribution and properties of human intestinal diamine oxidase and its relevance for the histamine catabolism (1983), Biochim. Biophys. Acta, 756, 196-203.
    View publication on PubMed
Search for more literature for 1.4.3.22

Inhibitors

Inhibitors Comment Organism Structure
aminoguanidine
-
 Canis lupus familiaris
aminoguanidine
-
 Cavia porcellus
aminoguanidine 0.00001 mM, 50% inhibition, putrescine or histamine as substrates Homo sapiens
aminoguanidine
-
 Mus musculus
aminoguanidine
-
 Oryctolagus cuniculus
aminoguanidine
-
 Rattus norvegicus
aminoguanidine
-
 Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.019
-
 histamine
-
 Homo sapiens
0.083
-
 putrescine
-
 Homo sapiens
0.097
-
 N(tau)-methylhistamine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Sus scrofa 5737
-
cytoplasm
-
 Canis lupus familiaris 5737
-
cytoplasm mainly in cytoplasm but to a considerable extent also in mitochondrial fraction Mus musculus 5737
-
cytoplasm mainly in cytoplasm but to a considerable extent also in mitochondrial fraction Homo sapiens 5737
-
cytoplasm mainly in cytoplasm but to a considerable extent also in mitochondrial fraction Rattus norvegicus 5737
-
cytoplasm chiefly in cytoplasm Mus musculus 5737
-
cytoplasm chiefly in cytoplasm Rattus norvegicus 5737
-
cytoplasm chiefly in cytoplasm Oryctolagus cuniculus 5737
-
mitochondrion mainly in cytoplasm but to a considerable extent also in mitochondrial fraction Mus musculus 5739
-
mitochondrion mainly in cytoplasm but to a considerable extent also in mitochondrial fraction Homo sapiens 5739
-
mitochondrion mainly in cytoplasm but to a considerable extent also in mitochondrial fraction Rattus norvegicus 5739
-
particle-bound
-
 Cavia porcellus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RCH2NH2 + H2O + O2 Rattus norvegicus
-
 RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2 Cavia porcellus enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2 Mus musculus enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2 Homo sapiens enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2 Sus scrofa enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2 Oryctolagus cuniculus enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2 Canis lupus familiaris enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis RCHO + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Cavia porcellus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colonic mucosa
-
 Oryctolagus cuniculus
-
colonic mucosa
-
 Canis lupus familiaris
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.012
-
-
 Homo sapiens

Storage Stability

Storage Stability Organism
-20°C, 24 h, 90% loss of activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,10-diaminodecane + H2O + O2
-
 Homo sapiens 10-aminodecanal + NH3 + H2O2
-
 ?
1,2-diaminoethane + H2O + O2
-
 Homo sapiens 2-aminoethanal + NH3 + H2O2
-
 ?
1,3-diaminopropane + H2O + O2
-
 Homo sapiens 3-aminopropanal + NH3 + H2O2
-
 ?
1,4-diaminobutane + H2O + O2
-
 Homo sapiens 4-aminobutanal + NH3 + H2O2
-
 ?
1,4-diaminobutane + H2O + O2
-
 Sus scrofa 4-aminobutanal + NH3 + H2O2
-
 ?
1,5-diaminopentane + H2O + O2
-
 Homo sapiens 5-aminopentanal + NH3 + H2O2
-
 ?
1,5-diaminopentane + H2O + O2
-
 Sus scrofa 5-aminopentanal + NH3 + H2O2
-
 ?
1,6-diaminohexane + H2O + O2
-
 Homo sapiens 6-aminohexanal + NH3 + H2O2
-
 ?
1,7-diaminoheptane + H2O + O2
-
 Homo sapiens 7-aminoheptanal + NH3 + H2O2
-
 ?
1,8-diaminooctane + H2O + O2
-
 Homo sapiens 8-aminooctanal + NH3 + H2O2
-
 ?
1,9-diaminononane + H2O + O2
-
 Homo sapiens 9-aminononanal + NH3 + H2O2
-
 ?
2-methylhistamine + H2O + O2
-
 Homo sapiens ?
-
 ?
5-methylhistamine + H2O + O2
-
 Homo sapiens ?
-
 ?
histamine + H2O + O2
-
 Homo sapiens (imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
 ?
histamine + H2O + O2
-
 Sus scrofa (imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
 ?
N(pi)-methylhistamine + H2O + O2
-
 Homo sapiens ?
-
 ?
N(tau)-methylhistamine + H2O + O2
-
 Homo sapiens ?
-
 ?
RCH2NH2 + H2O + O2
-
 Cavia porcellus RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2
-
 Mus musculus RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2
-
 Rattus norvegicus RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2
-
 Sus scrofa RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2
-
 Oryctolagus cuniculus RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2
-
 Canis lupus familiaris RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2 short-chain aliphatic diamines are deaminated with highest reaction velocity Homo sapiens RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2 enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis Cavia porcellus RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2 enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis Mus musculus RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2 enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis Homo sapiens RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2 enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis Sus scrofa RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2 enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis Oryctolagus cuniculus RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2 enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis Canis lupus familiaris RCHO + NH3 + H2O2
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.4 6.6 histamine Homo sapiens
6.6 7 putrescine Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6.2 7.8 pH 6.2 and pH 7.8: about 75% activity, putrescine Homo sapiens