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Literature summary for 1.4.3.2 extracted from

  • Pollegioni, L.; Motta, P.; Molla, G.
    L-amino acid oxidase as biocatalyst a dream too far? (2013), Appl. Microbiol. Biotechnol., 97, 9323-9341 .
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0044
-
L-Phe pH and temperature not specified in the publication Bacillus carotarum
0.016
-
L-Lys pH and temperature not specified in the publication Rhodococcus sp.
0.035
-
L-Lys pH and temperature not specified in the publication Rhodococcus sp. AIU LAB-3
1.1
-
L-Glu pH and temperature not specified in the publication Hebeloma cylindrosporum
11.8
-
L-Phe pH and temperature not specified in the publication Trichoderma harzianum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
gel filtration Pseudoalteromonas flavipulchra
63500
-
gel filtration Trichoderma harzianum
102000
-
gel filtration Rhodococcus sp.
105000
-
gel filtration Rhodococcus sp. AIU LAB-3
108000
-
gel filtration Bacillus carotarum
110000
-
gel filtration Pseudoalteromonas luteoviolacea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Ala + H2O + O2 Rhodococcus sp.
-
2-oxopropanoic acid + NH3 + H2O2
-
?
L-Ala + H2O + O2 Rhodococcus opacus
-
2-oxopropanoic acid + NH3 + H2O2
-
?
L-Ala + H2O + O2 Trichoderma harzianum
-
2-oxopropanoic acid + NH3 + H2O2
-
?
L-Ala + H2O + O2 Aspergillus fumigatus
-
2-oxopropanoic acid + NH3 + H2O2
-
?
L-Ala + H2O + O2 Rhodococcus sp. AIU LAB-3
-
2-oxopropanoic acid + NH3 + H2O2
-
?
L-Ala + H2O + O2 Trichoderma harzianum ETS 323
-
2-oxopropanoic acid + NH3 + H2O2
-
?
L-Ala + H2O + O2 Rhodococcus sp. AIU Z-35-1
-
2-oxopropanoic acid + NH3 + H2O2
-
?
L-Ala + H2O + O2 Rhodococcus opacus DSM 43250
-
2-oxopropanoic acid + NH3 + H2O2
-
?
L-Arg + H2O + O2 Rhodococcus sp. AIU LAB-3
-
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
?
L-Arg + H2O + O2 Bacillus carotarum
-
2-oxo-5-guanidinopentanoic acid + NH3 + H2O2
-
?
L-Asn + H2O + O2 Hebeloma cylindrosporum
-
2-oxosuccinamic acid + NH3 + H2O2
-
?
L-Asp + H2O + O2 Aspergillus fumigatus
-
oxaloacetate + NH3 + H2O2
-
?
L-Gln + H2O + O2 Rhodococcus sp.
-
5-amino-2,5-dioxopentanoic acid + NH3 + H2O2
-
?
L-Gln + H2O + O2 Hebeloma cylindrosporum
-
5-amino-2,5-dioxopentanoic acid + NH3 + H2O2
-
?
L-Gln + H2O + O2 Pseudoalteromonas luteoviolacea
-
5-amino-2,5-dioxopentanoic acid + NH3 + H2O2
-
?
L-Gln + H2O + O2 Pseudoalteromonas flavipulchra
-
5-amino-2,5-dioxopentanoic acid + NH3 + H2O2
-
?
L-Gln + H2O + O2 Rhodococcus sp. AIU LAB-3
-
5-amino-2,5-dioxopentanoic acid + NH3 + H2O2
-
?
L-Gln + H2O + O2 Rhodococcus sp. AIU Z-35-1
-
5-amino-2,5-dioxopentanoic acid + NH3 + H2O2
-
?
L-Glu + H2O + O2 Trichoderma harzianum
-
2-oxoglutarate + NH3 + H2O2
-
?
L-Glu + H2O + O2 Hebeloma cylindrosporum
-
2-oxoglutarate + NH3 + H2O2
-
?
L-Glu + H2O + O2 Pseudoalteromonas luteoviolacea
-
2-oxoglutarate + NH3 + H2O2
-
?
L-Glu + H2O + O2 Pseudoalteromonas flavipulchra
-
2-oxoglutarate + NH3 + H2O2
-
?
L-Glu + H2O + O2 Trichoderma harzianum ETS 323
-
2-oxoglutarate + NH3 + H2O2
-
?
L-His + H2O + O2 Rhodococcus sp.
-
2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
?
L-His + H2O + O2 Rhodococcus sp. AIU LAB-3
-
2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Aspergillus fumigatus
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Bacillus carotarum
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Pseudoalteromonas luteoviolacea
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2 Pseudoalteromonas flavipulchra
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Lys + H2O + O2 Trichoderma harzianum
-
6-amino-2-oxohexanoic acid + NH3 + H2O2
-
?
L-Lys + H2O + O2 Pseudoalteromonas flavipulchra
-
6-amino-2-oxohexanoic acid + NH3 + H2O2
-
?
L-Lys + H2O + O2 Bacillus carotarum
-
6-amino-2-oxo-hexanoic acid + NH3 + H2O2
-
?
L-Lys + H2O + O2 Rhodococcus sp.
-
6-amino-2-oxohexanoate + NH3 + H2O2
-
?
L-Lys + H2O + O2 Rhodococcus sp. AIU LAB-3
-
6-amino-2-oxohexanoate + NH3 + H2O2
-
?
L-Lys + H2O + O2 Trichoderma harzianum ETS 323
-
6-amino-2-oxohexanoic acid + NH3 + H2O2
-
?
L-Lys + H2O + O2 Rhodococcus sp. AIU Z-35-1
-
6-amino-2-oxohexanoate + NH3 + H2O2
-
?
L-Met + H2O + O2 Bacillus carotarum
-
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2 Pseudoalteromonas luteoviolacea
-
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2 Pseudoalteromonas flavipulchra
-
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2 Rhodococcus sp. AIU LAB-3
-
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Orn + H2O + O2 Rhodococcus sp.
-
2-oxo-5-aminopentanoate + NH3 + H2O2
-
?
L-Orn + H2O + O2 Rhodococcus sp. AIU LAB-3
-
2-oxo-5-aminopentanoate + NH3 + H2O2
-
?
L-Orn + H2O + O2 Rhodococcus sp. AIU Z-35-1
-
2-oxo-5-aminopentanoate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Trichoderma harzianum
-
2-oxo-3-phenylpropanoate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Aspergillus fumigatus
-
2-oxo-3-phenylpropanoate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Pseudoalteromonas luteoviolacea
-
2-oxo-3-phenylpropanoate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Pseudoalteromonas flavipulchra
-
2-oxo-3-phenylpropanoate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Rhodococcus sp. AIU LAB-3
-
2-oxo-3-phenylpropanoate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Bacillus carotarum highest catalytic efficiency 2-oxo-3-phenylpropanoate + NH3 + H2O2
-
?
L-Phe + H2O + O2 Trichoderma harzianum ETS 323
-
2-oxo-3-phenylpropanoate + NH3 + H2O2
-
?
L-Pro + H2O + O2 Aspergillus fumigatus
-
?
-
?
L-Ser + H2O + O2 Aspergillus fumigatus
-
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
?
L-Trp + H2O + O2 Pseudoalteromonas luteoviolacea
-
indol-3-pyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2 Rhodococcus sp.
-
4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2 Rhodococcus opacus
-
4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2 Aspergillus fumigatus
-
4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2 Pseudoalteromonas flavipulchra
-
4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2 Rhodococcus sp. AIU LAB-3
-
4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2 Rhodococcus sp. AIU Z-35-1
-
4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2 Rhodococcus opacus DSM 43250
-
4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
additional information Bacillus carotarum the enzyme is also active on D-isomers ?
-
?
additional information Rhodococcus opacus the enzyme is inactive on Gly, L-Thr and L-Pro ?
-
?
additional information Rhodococcus opacus DSM 43250 the enzyme is inactive on Gly, L-Thr and L-Pro ?
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus
-
-
-
Bacillus carotarum
-
-
-
Hebeloma cylindrosporum
-
-
-
Pseudoalteromonas flavipulchra
-
-
-
Pseudoalteromonas luteoviolacea
-
-
-
Rhodococcus opacus
-
-
-
Rhodococcus opacus DSM 43250
-
-
-
Rhodococcus sp.
-
-
-
Rhodococcus sp. AIU LAB-3
-
-
-
Rhodococcus sp. AIU Z-35-1
-
-
-
Trichoderma harzianum
-
-
-
Trichoderma harzianum ETS 323
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Trichoderma harzianum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala + H2O + O2
-
Rhodococcus sp. 2-oxopropanoic acid + NH3 + H2O2
-
?
L-Ala + H2O + O2
-
Rhodococcus opacus 2-oxopropanoic acid + NH3 + H2O2
-
?
L-Ala + H2O + O2
-
Trichoderma harzianum 2-oxopropanoic acid + NH3 + H2O2
-
?
L-Ala + H2O + O2
-
Aspergillus fumigatus 2-oxopropanoic acid + NH3 + H2O2
-
?
L-Ala + H2O + O2
-
Rhodococcus sp. AIU LAB-3 2-oxopropanoic acid + NH3 + H2O2
-
?
L-Ala + H2O + O2
-
Trichoderma harzianum ETS 323 2-oxopropanoic acid + NH3 + H2O2
-
?
L-Ala + H2O + O2
-
Rhodococcus sp. AIU Z-35-1 2-oxopropanoic acid + NH3 + H2O2
-
?
L-Ala + H2O + O2
-
Rhodococcus opacus DSM 43250 2-oxopropanoic acid + NH3 + H2O2
-
?
L-Arg + H2O + O2
-
Rhodococcus sp. AIU LAB-3 2-oxo-5-guanidinovaleric acid + NH3 + H2O2
-
?
L-Arg + H2O + O2
-
Bacillus carotarum 2-oxo-5-guanidinopentanoic acid + NH3 + H2O2
-
?
L-Asn + H2O + O2
-
Hebeloma cylindrosporum 2-oxosuccinamic acid + NH3 + H2O2
-
?
L-Asp + H2O + O2
-
Aspergillus fumigatus oxaloacetate + NH3 + H2O2
-
?
L-Gln + H2O + O2
-
Rhodococcus sp. 5-amino-2,5-dioxopentanoic acid + NH3 + H2O2
-
?
L-Gln + H2O + O2
-
Hebeloma cylindrosporum 5-amino-2,5-dioxopentanoic acid + NH3 + H2O2
-
?
L-Gln + H2O + O2
-
Pseudoalteromonas luteoviolacea 5-amino-2,5-dioxopentanoic acid + NH3 + H2O2
-
?
L-Gln + H2O + O2
-
Pseudoalteromonas flavipulchra 5-amino-2,5-dioxopentanoic acid + NH3 + H2O2
-
?
L-Gln + H2O + O2
-
Rhodococcus sp. AIU LAB-3 5-amino-2,5-dioxopentanoic acid + NH3 + H2O2
-
?
L-Gln + H2O + O2
-
Rhodococcus sp. AIU Z-35-1 5-amino-2,5-dioxopentanoic acid + NH3 + H2O2
-
?
L-Glu + H2O + O2
-
Trichoderma harzianum 2-oxoglutarate + NH3 + H2O2
-
?
L-Glu + H2O + O2
-
Hebeloma cylindrosporum 2-oxoglutarate + NH3 + H2O2
-
?
L-Glu + H2O + O2
-
Pseudoalteromonas luteoviolacea 2-oxoglutarate + NH3 + H2O2
-
?
L-Glu + H2O + O2
-
Pseudoalteromonas flavipulchra 2-oxoglutarate + NH3 + H2O2
-
?
L-Glu + H2O + O2
-
Trichoderma harzianum ETS 323 2-oxoglutarate + NH3 + H2O2
-
?
L-His + H2O + O2
-
Rhodococcus sp. 2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
?
L-His + H2O + O2
-
Rhodococcus sp. AIU LAB-3 2-oxo-4-imidazolepropionic acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Aspergillus fumigatus 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Bacillus carotarum 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Pseudoalteromonas luteoviolacea 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Leu + H2O + O2
-
Pseudoalteromonas flavipulchra 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
L-Lys + H2O + O2
-
Trichoderma harzianum 6-amino-2-oxohexanoic acid + NH3 + H2O2
-
?
L-Lys + H2O + O2
-
Pseudoalteromonas flavipulchra 6-amino-2-oxohexanoic acid + NH3 + H2O2
-
?
L-Lys + H2O + O2
-
Trichoderma harzianum ETS 323 6-amino-2-oxohexanoic acid + NH3 + H2O2
-
?
L-Lys + H2O + O2
-
Bacillus carotarum 6-amino-2-oxo-hexanoic acid + NH3 + H2O2
-
?
L-Lys + H2O + O2
-
Rhodococcus sp. 6-amino-2-oxohexanoate + NH3 + H2O2
-
?
L-Lys + H2O + O2
-
Rhodococcus sp. AIU LAB-3 6-amino-2-oxohexanoate + NH3 + H2O2
-
?
L-Lys + H2O + O2
-
Rhodococcus sp. AIU Z-35-1 6-amino-2-oxohexanoate + NH3 + H2O2
-
?
L-Met + H2O + O2
-
Bacillus carotarum 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2
-
Pseudoalteromonas luteoviolacea 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2
-
Pseudoalteromonas flavipulchra 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Met + H2O + O2
-
Rhodococcus sp. AIU LAB-3 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-Orn + H2O + O2
-
Rhodococcus sp. 2-oxo-5-aminopentanoate + NH3 + H2O2
-
?
L-Orn + H2O + O2
-
Rhodococcus sp. AIU LAB-3 2-oxo-5-aminopentanoate + NH3 + H2O2
-
?
L-Orn + H2O + O2
-
Rhodococcus sp. AIU Z-35-1 2-oxo-5-aminopentanoate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Trichoderma harzianum 2-oxo-3-phenylpropanoate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Aspergillus fumigatus 2-oxo-3-phenylpropanoate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Pseudoalteromonas luteoviolacea 2-oxo-3-phenylpropanoate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Pseudoalteromonas flavipulchra 2-oxo-3-phenylpropanoate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Rhodococcus sp. AIU LAB-3 2-oxo-3-phenylpropanoate + NH3 + H2O2
-
?
L-Phe + H2O + O2 highest catalytic efficiency Bacillus carotarum 2-oxo-3-phenylpropanoate + NH3 + H2O2
-
?
L-Phe + H2O + O2
-
Trichoderma harzianum ETS 323 2-oxo-3-phenylpropanoate + NH3 + H2O2
-
?
L-Pro + H2O + O2
-
Aspergillus fumigatus ?
-
?
L-Ser + H2O + O2
-
Aspergillus fumigatus 2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
?
L-Trp + H2O + O2
-
Pseudoalteromonas luteoviolacea indol-3-pyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2
-
Rhodococcus sp. 4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2
-
Rhodococcus opacus 4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2
-
Aspergillus fumigatus 4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2
-
Pseudoalteromonas flavipulchra 4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2
-
Rhodococcus sp. AIU LAB-3 4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2
-
Rhodococcus sp. AIU Z-35-1 4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
L-Tyr + H2O + O2
-
Rhodococcus opacus DSM 43250 4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
additional information the enzyme is also active on D-isomers Bacillus carotarum ?
-
?
additional information the enzyme is inactive on Gly, L-Thr and L-Pro Rhodococcus opacus ?
-
?
additional information the enzyme is inactive on Gly, L-Thr and L-Pro Rhodococcus opacus DSM 43250 ?
-
?

Subunits

Subunits Comment Organism
homodimer
-
Hebeloma cylindrosporum
homodimer 2 * 53000, SDS-PAGE Rhodococcus opacus
homodimer 2 * 51000, SDS-PAGE Rhodococcus sp.
homodimer 2 * 54000, SDS-PAGE Bacillus carotarum
homodimer 2 * 52500, SDS-PAGE Rhodococcus sp. AIU LAB-3
monomer or dimer
-
Trichoderma harzianum

Synonyms

Synonyms Comment Organism
LAAO
-
Rhodococcus sp.
LAAO
-
Rhodococcus opacus
LAAO
-
Trichoderma harzianum
LAAO
-
Aspergillus fumigatus
LAAO
-
Bacillus carotarum
LAAO
-
Hebeloma cylindrosporum
LAAO
-
Pseudoalteromonas luteoviolacea
LAAO
-
Pseudoalteromonas flavipulchra
LAAO
-
Rhodococcus sp. AIU LAB-3

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
45
-
-
Rhodococcus sp. AIU LAB-3
50
-
-
Rhodococcus sp.

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
17.6
-
L-Glu pH and temperature not specified in the publication Hebeloma cylindrosporum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Trichoderma harzianum
8
-
-
Rhodococcus sp.
8
-
-
Hebeloma cylindrosporum

Cofactor

Cofactor Comment Organism Structure
FAD
-
Rhodococcus sp.
FAD
-
Rhodococcus opacus
FAD
-
Trichoderma harzianum
FAD
-
Aspergillus fumigatus
FAD
-
Bacillus carotarum
FAD
-
Hebeloma cylindrosporum
FAD
-
Pseudoalteromonas luteoviolacea
FAD
-
Pseudoalteromonas flavipulchra
FAD
-
Rhodococcus sp. AIU LAB-3

pI Value

Organism Comment pI Value Maximum pI Value
Rhodococcus sp. isoelectric focusing
-
4.8
Rhodococcus opacus isoelectric focusing
-
4.8
Pseudoalteromonas flavipulchra isoelectric focusing
-
9.4