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Literature summary for 1.4.3.2 extracted from

  • Puiffe, M.L.; Lachaise, I.; Molinier-Frenkel, V.; Castellano, F.
    Antibacterial properties of the mammalian L-amino acid oxidase IL4I1 (2013), PLoS ONE, 8, e54589.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.3.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-phenylalanine + H2O + O2 Homo sapiens primary amino acid catabolized by IL4I1 phenylpyruvate + NH3 + H2O2
-
 ?
L-tryptophan + H2O + O2 Homo sapiens
-
 3-(1H-indol-3-yl)-2-oxopropanoate + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell
-
 Homo sapiens
-
macrophage
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-phenylalanine + H2O + O2 primary amino acid catabolized by IL4I1 Homo sapiens phenylpyruvate + NH3 + H2O2
-
 ?
L-tryptophan + H2O + O2
-
 Homo sapiens 3-(1H-indol-3-yl)-2-oxopropanoate + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
IL4I1
-
 Homo sapiens
IL4I1 interleukin 4 induced gene 1 Homo sapiens
L-amino acid oxidase
-
 Homo sapiens
LAAO
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function IL41I inhibits bacterial growth. The antibiotic action of IL4I1 is mainly due to H2O2 and NH3 production whereas its L-amino acid oxidase activity does not sufficiently deplete the medium of Phe or Trp to inhibit bacterial growth Homo sapiens