Literature summary for 1.4.3.2 extracted from

Carbonnelle-Puscian, A.; Copie-Bergman, C.; Baia, M.; Martin-Garcia, N.; Allory, Y.; Haioun, C.; Cremades, A.; Abd-Alsamad, I.; Farcet, J.; Gaulard, P.; Castellano, F.; Molinier-Frenkel, V.
The novel immunosuppressive enzyme IL4I1 is expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrophages (2009), Leukemia, 23, 952-960.

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Application

Application	Comment	Organism
medicine	a high level of enzyme expression seems associated with absence of bone marrow involvement and better outcome in follicular lymphoma cases, enzyme levels could serve as prognosis factor	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-phenylalanine + H2O + O2	Homo sapiens	inhibition of T cell proliferation through phenylalanine degradation	phenylpyruvate + NH3 + H2O2	activity measurement by measuring H2O2 production	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	lymphoid and non lymphoid malignancies, lymphoma cell lines L428, KM-H2, and SU-DHL-4	-

Purification (Commentary)

Purification (Comment)	Organism
whole cell lysates of viable cryopreserved lymph node cells from follicular lymphomas, spelnocytes from marginal zone lymphoma, and traumatic normal spleens, and cell lines or cells are submitted to magnetic cell sorting using anti-human CD19 MACS beads	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
B-cell lymphoma cell	most primary mediastinal B-cell lymphoma (89%) are positive for enzyme immunostaining with strong intracytoplasmic staining in up to 100% of tumor cells, CD19(+) and CD19(-) cells display enzyme activity	Homo sapiens	-
follicular lymphoma cell	64% positive immunostaining, no correlation between staining and histological grade of the follicular lymphoma, in small lymphocytic lymphoma 40% positive, restricted to paraimmunoblasts of proliferative centers, high enzyme activity, 7fold higher than in spleen lysate	Homo sapiens	-
histiocyte	variable percentage of positive staining in several tissues, solid tumors, interfollicular areas, sinuses of reactive lymph nodes, red pulp of lymphoid follicles, thymus medulla, all lymphoma subtypes, particularly high enzyme expression in classical Hodgkin lymphoma and nodular lymphocyte predominant Hodgkin lymphoma cells	Homo sapiens	-
lymphoma cell	42% positive staining of classical Hodgkin lymphoma in Hodgkin and Reed Sternberg cells, 91% positive staining of nodular lymphocyte predominant Hodgkin lymphoma cells	Homo sapiens	-
macrophage	immunostaining in macrophages associated with non small-cell lung carcinomas, mesotheliomas, colorectal carcinomas and testicular germ cell tumors, positive staining in germinal centers of reactive lymph nodes and hyperplastic tonsils, and in the spleen	Homo sapiens	-
additional information	enzyme expression in solid tumors only in 7.4% of 121 cases (5/10 mesotheliomas, 2/13 non small-cell carcinomas, 1/6 thyroid carcinoma, and 1/3 ovarian carcinoma), observations suggest aril in inflammatory processes, only occasional positive staining (17%) of non-mediastinal diffuse large B cell lymphoma	Homo sapiens	-
additional information	strong enzyme activity in L428 cell-line associated with detectable enzyme secretion, higher enzymatic activity than in SU-DHL-4 cells, higher enzyme activity in KM-H2 cell line than in Su-DHL-4 cells but lower than in L428 cells, total tumor cell lysate with negligible enzyme activity, CD19(+) fraction of marginal zone lymphoma cell with negligible enzyme activity, some activity in CD19(-) stromal cells	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-phenylalanine + H2O + O2	inhibition of T cell proliferation through phenylalanine degradation	Homo sapiens	phenylpyruvate + NH3 + H2O2	activity measurement by measuring H2O2 production	?

Synonyms

Synonyms	Comment	Organism
IL4I1	-	Homo sapiens
Il4i1 protein	secreted L-phenylalanine oxidase, physiologically expressed by myeloid cells, gene expression in primary mediastinal B-cell lymphoma	Homo sapiens
Interleukin Four Induced Gene 1 protein	first described in the mouse, characterized in human B cells, expression is restricted to lymphoid tissues and induced by interleukin-4	Homo sapiens
L-phenylalanine oxidase	-	Homo sapiens

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Release 2023.1 (January 2023)