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Literature summary for 1.4.3.14 extracted from

  • Murthy, S.N.; Janardanasarma, M.K.
    Identification of L-amino acid/L-lysine alpha-amino oxidase in mouse brain (1999), Mol. Cell. Biochem., 197, 13-23.
    View publication on PubMed
Search for more literature for 1.4.3.14

Application

Application Comment Organism
medicine antitumor activity Trichoderma viride

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine + O2 + H2O Mus musculus
-
 6-amino-2-oxohexanoate + NH3 + H2O2
-
 ?
L-lysine + O2 + H2O Trichoderma viride
-
 6-amino-2-oxohexanoate + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 fasted
-
Trichoderma viride
-
-
-

Purification (Commentary)

Purification (Comment) Organism
gel-filtration Mus musculus

Reaction

Reaction Comment Organism Reaction ID
L-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + H2O2 catabolic pathway of L-lysine through the pipecolic acid pathway Mus musculus
a

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Trichoderma viride
additional information
-
 activity is higher in the brain of mice which are fasted Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-leucine + O2 + H2O
-
 Mus musculus 4-methyl-2-oxopentanoate + NH3 + H2O2
-
 ?
L-leucine + O2 + H2O
-
 Trichoderma viride 4-methyl-2-oxopentanoate + NH3 + H2O2
-
 ?
L-lysine + O2 + H2O
-
 Mus musculus 6-amino-2-oxohexanoate + NH3 + H2O2
-
 ?
L-lysine + O2 + H2O
-
 Trichoderma viride 6-amino-2-oxohexanoate + NH3 + H2O2
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus
37
-
 assay at Trichoderma viride

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus
7.4
-
 assay at Trichoderma viride

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Trichoderma viride
FAD tightly bound Mus musculus