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Literature summary for 1.4.3.13 extracted from

  • Herchenhan, A.; Uhlenbrock, F.; Eliasson, P.; Weis, M.; Eyre, D.; Kadler, K.E.; Magnusson, S.P.; Kjaer, M.
    Lysyl oxidase activity is required for ordered collagen fibrillogenesis by tendon cells (2015), J. Biol. Chem., 290, 16440-16450 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.3.13

Inhibitors

Inhibitors Comment Organism Structure
beta-aminopropionitrile competitive inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptidyl-L-lysyl-peptide + O2 + H2O Homo sapiens
-
 peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
tendon fibroblast
-
 Homo sapiens
-
tenocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptidyl-L-lysyl-peptide + O2 + H2O
-
 Homo sapiens peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
LOX
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme inhibition stops early mechanical development of tendon constructs and leads to irregularly shaped collagen fibrils Homo sapiens
physiological function lysyl oxidase activity is required for ordered collagen fibrillogenesis by tendon cells Homo sapiens