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Literature summary for 1.4.3.13 extracted from

  • Molnar, J.; Fong, K.S.K.; He, Q.P.; Hayashi, K.; Kim, Y.; Fong, S.F.T.; Fogelgren, B.; Molnarne Szauter, K.; Mink, M.; Csiszar, K.
    Structural and functional diversity of lysyl oxidase and the LOX-like proteins (2003), Biochim. Biophys. Acta, 1647, 220-224.
    View publication on PubMed
Search for more literature for 1.4.3.13

Inhibitors

Inhibitors Comment Organism Structure
beta-aminopropionitrile inhibition of LOXL-1 Drosophila melanogaster
beta-aminopropionitrile selective inhibition of mammalian LOX Homo sapiens
beta-aminopropionitrile selective inhibition of mammalian LOX Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular matrix LOX, LOXL Homo sapiens 31012
-
additional information lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 show individual, developmentally regulated tissue and cell-specific expression and localization Mus musculus
-
-
additional information lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 show individual, developmentally regulated tissue and cell-specific expression and localization Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ copper-cofactor, lysyl oxidase and LOX-like proteins LOXL-1 and LOXL-2, conserved binding domain Drosophila melanogaster
Cu2+ lysyl oxidase and LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 Mus musculus
Cu2+ lysyl oxidase and LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens LOX induced chromatin changes, mechanism via histone deamination ?
-
 ?
additional information Drosophila melanogaster LOX induced chromatin changes, mechanism via histone deamination ?
-
 ?
peptidyl-L-lysyl-peptide + O2 + H2O Mus musculus
-
 peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?
peptidyl-L-lysyl-peptide + O2 + H2O Homo sapiens
-
 peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?
peptidyl-L-lysyl-peptide + O2 + H2O Drosophila melanogaster
-
 peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9N9Y8 LOXL-2; lysyl oxidase and 2 LOX-like proteins LOXL and LOXL2
-
Drosophila melanogaster Q9V9X5 LOXL-1; lysyl oxidase and 2 LOX-like proteins LOXL and LOXL2
-
Homo sapiens
-
 structurally and functionally diverse enzyme forms: lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4, probably existing splicing variants of LOXL3
-
Mus musculus
-
 adult B6SJLF1 mice, structurally and functionally diverse enzyme forms: lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4, probably existing splicing variants of LOXL3
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification N-terminal processing by BMP-1 of lysyl oxidase and LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 in the extracellular matrix results in active proteins Mus musculus
proteolytic modification N-terminal processing by BMP-1 of lysyl oxidase and LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 in the extracellular matrix results in active proteins Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
aorta LOX, LOXL, LOXL3, low expression level of LOXL2 Homo sapiens
-
embryo LOXL-1 Drosophila melanogaster
-
embryo LOXL-1, no expression of LOXL-2 Drosophila melanogaster
-
heart only in fetal heart, LOXL2, very low expression level of LOXL3 Homo sapiens
-
kidney LOXL4, LOX, LOXL Homo sapiens
-
larva LOXL-1 Drosophila melanogaster
-
larva LOXL-1, no expression of LOXL-2 Drosophila melanogaster
-
lung LOXL4, LOX, LOXL Homo sapiens
-
additional information adult fly: LOXL and LOXL-2, the latter occurs exclusively in adult flies, developmental expression analysis of LOX-like proteins LOXL and LOXL2 in embryos, larvae, pupae, and adult flies, no expression of LOXL-2 in larvae, pupae, and embryos, overview Drosophila melanogaster
-
additional information adult fly: LOXL and LOXL-2, the latter occurs exclusively in adult flies, developmental expression analysis of LOX-like proteins LOXL and LOXL2 in embryos, larvae, pupae, and adult flies, overview Drosophila melanogaster
-
additional information lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 show individual, developmentally regulated tissue and cell-specific expression and localization Mus musculus
-
additional information lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 show individual, developmentally regulated tissue and cell-specific expression and localization, expression patterns, LOX and LOXL are expressed in most tissues Homo sapiens
-
ovary LOXL4, LOX, LOXL Homo sapiens
-
pancreas LOXL4, LOX, LOXL Homo sapiens
-
placenta LOXL4, LOXL2, LOX, LOXL Homo sapiens
-
prostate LOXL2, LOX, LOXL Homo sapiens
-
pupa LOXL-1 Drosophila melanogaster
-
pupa LOXL-1, no expression of LOXL-2 Drosophila melanogaster
-
testis LOXL4, LOX, LOXL Homo sapiens
-
uterus LOXL2, LOX, LOXL Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information LOX induced chromatin changes, mechanism via histone deamination Homo sapiens ?
-
 ?
additional information LOX induced chromatin changes, mechanism via histone deamination Drosophila melanogaster ?
-
 ?
additional information lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 all contain a cytokine receptor-like domain Mus musculus ?
-
 ?
additional information lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 all contain a cytokine receptor-like domain Homo sapiens ?
-
 ?
peptidyl-L-lysyl-peptide + O2 + H2O
-
 Mus musculus peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?
peptidyl-L-lysyl-peptide + O2 + H2O
-
 Homo sapiens peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?
peptidyl-L-lysyl-peptide + O2 + H2O
-
 Drosophila melanogaster peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?

Subunits

Subunits Comment Organism
More domain structure of LOX-like protein Drosophila melanogaster
More domain structure of LOX-like protein, LOXL-1 and LOXL-2 contain SRCR domains Drosophila melanogaster
More the enzymes contain SRCR domains Homo sapiens

Synonyms

Synonyms Comment Organism
LOX
-
 Mus musculus
LOX
-
 Homo sapiens
LOX
-
 Drosophila melanogaster
LOX-like protein
-
 Drosophila melanogaster
LOXL
-
 Mus musculus
LOXL
-
 Homo sapiens
LOXL
-
 Drosophila melanogaster
lysyl oxidase
-
 Mus musculus
lysyl oxidase
-
 Homo sapiens
lysyl oxidase
-
 Drosophila melanogaster
lysyl oxidase-like protein
-
 Mus musculus
lysyl oxidase-like protein
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
quinone lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 all contain conserved lysyl and tyrosyl residues that may contribute to quinone cofactor formation Mus musculus
quinone lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 all contain conserved lysyl and tyrosyl residues that may contribute to quinone cofactor formation Homo sapiens