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Literature summary for 1.4.1.B2 extracted from

  • Zhang, D.; Chen, X.; Zhang, R.; Yao, P.; Wu, Q.; Zhu, D.
    Development of beta-amino acid dehydrogenase for the synthesis of beta-amino acids via reductive amination of beta-keto acids (2015), ACS Catal., 5, 2220-2224 .
No PubMed abstract available
Search for more literature for 1.4.1.B2

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Candidatus Cloacimonas acidaminovorans

Protein Variants

Protein Variants Comment Organism
E310G the mutant exhibits activity towards (S)-beta-aminobutyric acid, beta-alanine, (R)-beta-homoserine, (R)-beta-homomethionine, (S)-beta-homoglutamine, (R)-beta-phenylalanine, and (S)-beta-homolysine Candidatus Cloacimonas acidaminovorans
E310G/A314Y the mutant exhibits activity towards (S)-beta-aminobutyric acid, beta-alanine, (R)-beta-homoserine, (R)-beta-homomethionine, (S)-beta-homoglutamine, (R)-beta-phenylalanine, and (S)-beta-homolysine Candidatus Cloacimonas acidaminovorans
E310S the mutant exhibits activity towards (S)-beta-aminobutyric acid, beta-alanine, (R)-beta-homoserine, (R)-beta-homomethionine, (S)-beta-homoglutamine, (R)-beta-phenylalanine, and (S)-beta-homolysine Candidatus Cloacimonas acidaminovorans
E310S/A314N the mutant exhibits activity towards (S)-beta-aminobutyric acid, beta-alanine, (R)-beta-homoserine, (R)-beta-homomethionine, (S)-beta-homoglutamine, (R)-beta-phenylalanine, and (S)-beta-homolysine Candidatus Cloacimonas acidaminovorans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-erythro-3,5-diaminohexanoate + H2O + NADP+ Candidatus Cloacimonas acidaminovorans
-
 (S)-5-amino-3-oxohexanoate + NH3 + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Candidatus Cloacimonas acidaminovorans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-erythro-3,5-diaminohexanoate + H2O + NADP+
-
 Candidatus Cloacimonas acidaminovorans (S)-5-amino-3-oxohexanoate + NH3 + NADPH + H+
-
 ?
additional information the enzyme barely shows any activity towards (S)-beta-aminobutyric acid, beta-alanine, (R)-beta-homoserine, (R)-beta-homomethionine, (S)-beta-homoglutamine, (R)-beta-phenylalanine, and (S)-beta-homolysine Candidatus Cloacimonas acidaminovorans ?
-
 ?

Synonyms

Synonyms Comment Organism
3,5-DAHDH
-
 Candidatus Cloacimonas acidaminovorans

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Candidatus Cloacimonas acidaminovorans