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Literature summary for 1.4.1.4 extracted from

  • Turner, A.C.; Lushbaugh, W.B.
    Trichomonas vaginalis: characterization of its glutamate dehydrogenase (1988), Exp. Parasitol., 67, 47-53.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
GDP at 1 mM five-fold Michaelis Menten constant of 2-oxoglutarate Trichomonas vaginalis
IDP at 1 mM five-fold Michaelis Menten constant of 2-oxoglutarate Trichomonas vaginalis

Inhibitors

Inhibitors Comment Organism Structure
2-oxoglutarate competitive inhibitor of the deamination Trichomonas vaginalis
glutamate competitive inhibitor of the amination reaction Trichomonas vaginalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
NADPH reductive amination Trichomonas vaginalis
0.04
-
NADP+ oxidative deamination Trichomonas vaginalis

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Trichomonas vaginalis
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
230000
-
gel filtration Trichomonas vaginalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate + NADP+ + H2O Trichomonas vaginalis
-
2-oxoglutarate + NADPH + NH3
-
r

Organism

Organism UniProt Comment Textmining
Trichomonas vaginalis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially Trichomonas vaginalis

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
133
-
reductive amination at 37°C and pH 6.7 Trichomonas vaginalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate + NADP+ + H2O
-
Trichomonas vaginalis 2-oxoglutarate + NADPH + NH3
-
r

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
57
-
after 1 h stable Trichomonas vaginalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.7
-
reductive amination Trichomonas vaginalis
8
-
oxidative deamination Trichomonas vaginalis

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Trichomonas vaginalis
NADPH
-
Trichomonas vaginalis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.45
-
2-oxoglutarate competitive Trichomonas vaginalis
5.6
-
glutamate competitive inhibitor Trichomonas vaginalis