Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.4.1.3 extracted from

  • Haghighi, O.; Davaeifar, S.; Zahiri, H.; Maleki, H.; Noghabi, K.
    Homology modeling and molecular docking studies of glutamate dehydrogenase (GDH) from cyanobacterium Synechocystis sp. PCC 6803 (2020), Int. J. Pept. Res. Ther., 26, 783-793 .
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
L-glutamate a competitive inhibitor against GDH Synechocystis sp. PCC 6803

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate + H2O + NAD(P)+ Synechocystis sp. PCC 6803
-
2-oxoglutarate + NH3 + NAD(P)H + H+
-
r

Organism

Organism UniProt Comment Textmining
Synechocystis sp. PCC 6803 P73684
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate + H2O + NAD(P)+
-
Synechocystis sp. PCC 6803 2-oxoglutarate + NH3 + NAD(P)H + H+
-
r
additional information the binding affinity of L-glutamate is lower than that of 2-oxoglutarate. Hence, L-glutamate has a weaker affinity than 2-oxoglutarate in binding to the active site of GDH. A comparison of binding site in 2-oxoglutarate and L-glutamate indicate three residues which include Arg401, Trp88, and Arg12 that have important role in interaction between these ligands with active site of GDH Synechocystis sp. PCC 6803 ?
-
-

Subunits

Subunits Comment Organism
More sequence comparisons and GDH structure homology modeling studies, overview Synechocystis sp. PCC 6803

Synonyms

Synonyms Comment Organism
GDH
-
Synechocystis sp. PCC 6803

Cofactor

Cofactor Comment Organism Structure
additional information coenzyme specificity of GDH for NADPH and NADH Synechocystis sp. PCC 6803
NAD+
-
Synechocystis sp. PCC 6803
NADH
-
Synechocystis sp. PCC 6803
NADP+
-
Synechocystis sp. PCC 6803
NADPH
-
Synechocystis sp. PCC 6803

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.686
-
L-glutamate pH and temperature not specified in the publication Synechocystis sp. PCC 6803

General Information

General Information Comment Organism
additional information sequence comparisons and GDH structure homology modeling studies and docking analyses of NADPH, NADH, 2-oxoglutarate, and L-glutamate into the predictive model of GDH, loop modeling, overview Synechocystis sp. PCC 6803