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Literature summary for 1.2.7.4 extracted from

  • Lu, W.P.; Ragsdale, S.W.
    Reductive activation of the coenzyme A/acetyl-CoA isotopic exchange reaction catalyzed by carbon monoxide dehydrogenase from Clostridium thermoaceticum and its inhibition by nitrous oxide and carbon monoxide (1991), J. Biol. Chem., 266, 3554-3564.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
CN- 1.2 mM, 98% inhibition of acetyl-CoA/CoA exchange reaction Moorella thermoacetica
CO inhibition of the exchange reaction between acetyl-CoA and CoA Moorella thermoacetica
N2O inhibition of the exchange reaction between acetyl-CoA and CoA Moorella thermoacetica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CO + H2O + electron acceptor Moorella thermoacetica the enzyme is involved in the Wood pathway of acetyl-CoA synthesis ?
-
?

Organism

Organism UniProt Comment Textmining
Moorella thermoacetica
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7
-
acetyl-CoA/CoA exchange reaction at pH 6.0 and 45°C, 100% CO in the gas phase Moorella thermoacetica
28
-
acetyl-CoA/CoA exchange reaction at pH 6.0 and 45°C, CO in the gas phase replaced by N2 Moorella thermoacetica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO + H2O + electron acceptor the enzyme is involved in the Wood pathway of acetyl-CoA synthesis Moorella thermoacetica ?
-
?
CO + H2O + FMN
-
Moorella thermoacetica CO2 + FMNH2
-
?
CO + H2O + methyl viologen catalyzes the exchange reaction between coenzyme A and acetyl-CoA Moorella thermoacetica CO2 + reduced methyl viologen
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.4
-
CO inhibition of acetyl-CoA/CoA exchange reaction Moorella thermoacetica