Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | Q60597 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
culture condition:CD34+ cell | - |
Homo sapiens | - |
erythrocyte | - |
Mus musculus | - |
hematopoietic stem cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
KDH | alpha-ketoglutarate dehydrogenase is composed of 3 subunits: oxoglutarate dehydrogenase (E1), dihydrolipoamide S-succinyltransferase (E2), and dihydrolipoamide dehydrogenase (E3) | Homo sapiens |
Kdh E1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | during late stages of erythropoiesis, cellular metabolism is remodeled so that glutamine is the precursor for 5-aminolevulinate following deamination to 2-oxoglutarate and conversion to succinyl-CoA by 2-oxoglutarate dehydrogenase without equilibration or passage through the TCA cycle. This may be facilitated by a direct interaction between 5-aminolevulinate synthase 2 and 2-oxoglutarate dehydrogenase. Succinate is not an effective precursor for heme | Mus musculus |