Literature summary for 1.2.4.2 extracted from

Kinugawa, H.; Kondo, N.; Komine-Abe, A.; Tomita, T.; Nishiyama, M.; Kosono, S.
In vitro reconstitution and characterization of pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase hybrid complex from Corynebacterium glutamicum (2020), MicrobiologyOpen, 9, e1113 .

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Organism

Organism	UniProt	Comment	Textmining
Corynebacterium glutamicum	Q8NRC3	-	-
Corynebacterium glutamicum ATCC 13869	Q8NRC3	-	-

Synonyms

Synonyms	Comment	Organism
2-oxoglutarate dehydrogenase E1/E2 component	-	Corynebacterium glutamicum
OdhA	-	Corynebacterium glutamicum

General Information

General Information	Comment	Organism
physiological function	in Corynebacterium glutamicum, the PDH-ODH hybrid complex consists of six copies of subunit E2 in its core. E2 forms a stable complex with E3 (E2-E3 subcomplex) in vitro, hypothetically comprised of two E2 trimers and four E3 dimers. E1o exists mainly as a hexamer in solution and is ready to form an active ODH complex when mixed with the E2-E3 subcomplex. Inhibition of ODH and PDH is E1p- and E1o-dependent, respectively, actively supporting the formation Iof the hybrid complex, in which both E1p and E1o associate with a single E2-E3	Corynebacterium glutamicum

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Release 2023.1 (January 2023)