Literature summary for 1.2.4.2 extracted from

Choi, S.; Pfleger, J.; Jeon, Y.; Yang, Z.; He, M.; Shin, H.; Sayed, D.; Astrof, S.; Abdellatif, M.
Oxoglutarate dehydrogenase and acetyl-CoA acyltransferase 2 selectively associate with H2A.Z-occupied promoters and are required for histone modifications (2019), Biochim. Biophys. Acta, 1862, 194436 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Homo sapiens	5634	-
nucleus	-	Mus musculus	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q02218	-	-
Mus musculus	Q60597	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HAP-1 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	histone H2A.Z-bound chromatin is associated with metabolic enzymes, oxoglutarate dehydrogenase (OGDH) and acetyl-CoA acyltransferase 2 (ACAA2) in the nucleus. OGDH and ACAA2 predominantly associate with H2A.Z-occupied transcription start sites and enhancers	Mus musculus
physiological function	histone H2A.Z-deficient human HAP1 cells exhibit reduced chromatin-bound metabolic enzymes, accompanied with reduced posttranslational histone modifications, including acetylation and succinylation. Knockdown of OGDH diminishes histone H4 succinylation	Homo sapiens

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Release 2023.1 (January 2023)