Literature summary for 1.2.3.1 extracted from

Acheampong, A.A.; Chien, D.S.; Lam, S.; Vekich, S.; Breau, A.; Usansky, J.; Harcourt, D.; Munk, S.A.; Nguyen, H.; Garst, M.; Tang-Liu, D.
Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase (1996), Xenobiotica, 26, 1035-1055.

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Inhibitors

Inhibitors	Comment	Organism	Structure
menadione	complete inhibition at 0.05 mM	Oryctolagus cuniculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-
cytosol	-	Oryctolagus cuniculus	5829	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3 brimonidine + 4 H2O + 4 O2	Rattus norvegicus	-	2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2	-	?
3 brimonidine + 4 H2O + 4 O2	Oryctolagus cuniculus	-	2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2	-	?
3 brimonidine + 4 H2O + 4 O2	Canis lupus familiaris	-	2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2	-	?
3 brimonidine + 4 H2O + 4 O2	Macaca fascicularis	-	2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Canis lupus familiaris	-	-	-
Macaca fascicularis	-	monkey	-
Oryctolagus cuniculus	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-
liver	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3 brimonidine + 4 H2O + 4 O2	-	Rattus norvegicus	2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2	-	?
3 brimonidine + 4 H2O + 4 O2	-	Oryctolagus cuniculus	2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2	-	?
3 brimonidine + 4 H2O + 4 O2	-	Canis lupus familiaris	2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2	-	?
3 brimonidine + 4 H2O + 4 O2	-	Macaca fascicularis	2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2	-	?

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Release 2023.1 (January 2023)