Literature summary for 1.2.1.8 extracted from

Velasco-Garcia, R.; Zaldivar-Machorro, V.J.; Mujica-Jimenez, C.; Gonzalez-Segura, L.; Munoz-Clares, R.A.
Disulfiram irreversibly aggregates betaine aldehyde dehydrogenase--a potential target for antimicrobial agents against Pseudomonas aeruginosa (2006), Biochem. Biophys. Res. Commun., 341, 408-415.

Search for more literature for 1.2.1.8

Application

Application	Comment	Organism
medicine	betaine aldehyde dehydrogenase is a potential target for antimicrobial agents against Pseudomonas aeruginosa	Pseudomonas aeruginosa

Cloned(Commentary)

Cloned (Comment)	Organism
wild type Pseudomonas aeruginosa betaine aldehyde dehydrogenase and the four mutants C353A, C377A, C439A and C286A	Pseudomonas aeruginosa

Protein Variants

Protein Variants	Comment	Organism
C286A	cysteine 286 plays an important role in the maintenance ot the tetrameric structure	Pseudomonas aeruginosa
C353A	cysteine 353 not essential for enzyme activity	Pseudomonas aeruginosa
C377A	cysteine 377 not essential for enzyme activity	Pseudomonas aeruginosa
C439A	cysteine 439 not essential for enzyme activity	Pseudomonas aeruginosa

Inhibitors

Inhibitors	Comment	Organism	Structure
5,5'-dithiobis[2-nitrobenzoic acid]	the effect of the thiol reagent DTNB on the native enzyme structure of the wild type enzyme and the mutants is examined	Pseudomonas aeruginosa
bis[diethylthiocarbamyl]disulfide	the effect of the thiol reagent disulfiram on the native enzyme structure of the wild type enzyme and the mutants is examined	Pseudomonas aeruginosa
S-methylmethanesulfonate	the effect of the thiol reagent MMTS on the native enzyme structure of the wild type enzyme and the mutants is examined	Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
betaine aldehyde + NAD(P)+ + H2O	Pseudomonas aeruginosa	-	glycine betaine + NAD(P)H + 2 H+	-	ir

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
purified to homogeneity following a two-step procedure	Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
betaine aldehyde + NAD(P)+ + H2O	-	Pseudomonas aeruginosa	glycine betaine + NAD(P)H + 2 H+	-	ir

Subunits

Subunits	Comment	Organism
tetramer	-	Pseudomonas aeruginosa

Synonyms

Synonyms	Comment	Organism
betaine aldehyde dehydrogenase	-	Pseudomonas aeruginosa
betaine aldehyde:NAD(P)+ oxidoreductase	-	Pseudomonas aeruginosa
PaBADH	-	Pseudomonas aeruginosa

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	activity assay	Pseudomonas aeruginosa

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	activity assay	Pseudomonas aeruginosa

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)