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Literature summary for 1.2.1.60 extracted from

  • Cooper, R.A.; Skinner, M.A.
    Catabolism of 3- and 4-hydroxyphenylacetate by the 3,4-dihydroxyphenylacetate pathway in Escherichia coli (1980), J. Bacteriol., 143, 302-306.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ Escherichia coli involved in the meta-cleavage pathway of 4-hydroxyphenylacetate 5-carboxymethyl-2-hydroxymuconate + NADH
-
 ?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ Escherichia coli B / ATCC 11303 involved in the meta-cleavage pathway of 4-hydroxyphenylacetate 5-carboxymethyl-2-hydroxymuconate + NADH
-
 ?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ Escherichia coli C involved in the meta-cleavage pathway of 4-hydroxyphenylacetate 5-carboxymethyl-2-hydroxymuconate + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli B / ATCC 11303
-
-
-
Escherichia coli C
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
 Escherichia coli
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ involved in the meta-cleavage pathway of 4-hydroxyphenylacetate Escherichia coli 5-carboxymethyl-2-hydroxymuconate + NADH
-
 ?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ involved in the meta-cleavage pathway of 4-hydroxyphenylacetate Escherichia coli B / ATCC 11303 5-carboxymethyl-2-hydroxymuconate + NADH
-
 ?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ involved in the meta-cleavage pathway of 4-hydroxyphenylacetate Escherichia coli C 5-carboxymethyl-2-hydroxymuconate + NADH
-
 ?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NADP+ 1,5% of the activity compared to reduction with NAD+ Escherichia coli 5-carboxymethyl-2-hydroxymuconate + NADPH
-
 ?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NADP+ 1,5% of the activity compared to reduction with NAD+ Escherichia coli B / ATCC 11303 5-carboxymethyl-2-hydroxymuconate + NADPH
-
 ?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NADP+ 1,5% of the activity compared to reduction with NAD+ Escherichia coli C 5-carboxymethyl-2-hydroxymuconate + NADPH
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Escherichia coli
NADP+ 98.5% lower activity compared to NAD+ Escherichia coli