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Literature summary for 1.2.1.49 extracted from

  • Vander Jagt, D.L.; Davidson, L.M.
    Purification and characterization of 2-oxoaldehyde dehydrogenase from rat liver (1977), Biochim. Biophys. Acta, 484, 260-267.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
D,L-2-amino-1-propanol activation of aldehyde oxidation Rattus norvegicus
L-serine methyl ester activation of aldehyde oxidation Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.14
-
methylglyoxal
-
Rattus norvegicus
0.21 0.83 methylglyoxal
-
Rattus norvegicus
0.8
-
NADP+
-
Rattus norvegicus
8
-
methylglyoxal amine as activator in aldehyde oxidation Rattus norvegicus
8
-
methylglyoxal in the presence of L-serine methyl ester (Km 8.0 mM) Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methylglyoxal + NADP+ + H2O Rattus norvegicus ir pyruvate + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
using ammonium sulfate fractionation and chromatography on DEAE-Sephadex column, Blue-dextran affinity column and CM-Sephadex column Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus
7.25
-
-
Rattus norvegicus

Storage Stability

Storage Stability Organism
-20°C, 50% glycerol Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methylglyoxal + NADP+ + H2O ir Rattus norvegicus pyruvate + NADPH + H+
-
?
additional information the only known amine which activates the enzyme at physiological pH is L-serine methyl ester, L-2-amino-1-propanol gives very little activity but D,L-2-amino-1-propanol activates the enzyme Rattus norvegicus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
9.3
-
activity falls abruptly above Rattus norvegicus

pH Stability

pH Stability pH Stability Maximum Comment Organism
9.3
-
not stable above Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Rattus norvegicus