Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.2.1.49 extracted from

  • Jellum, E.
    Metabolism of the ketoaldehyde 2-keto-3-deoxyglucose (1968), Biochim. Biophys. Acta, 165, 357-363.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.4
-
NADP+
-
Ovis aries
1.2
-
2-keto-3-deoxy-D-glucose
-
Ovis aries

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-keto-3-deoxy-D-glucose + NADP+ + H2O Rattus norvegicus
-
2-keto-3-deoxy-D-gluconic acid + NADPH + H+
-
?
2-keto-3-deoxy-D-glucose + NADP+ + H2O Ovis aries
-
2-keto-3-deoxy-D-gluconic acid + NADPH + H+
-
?
methylglyoxal + NADP+ + H2O Rattus norvegicus
-
pyruvate + NADPH + H+
-
?
methylglyoxal + NADP+ + H2O Ovis aries
-
pyruvate + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Ovis aries
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
using treatment with acetone, ammonium sulfate fractionation, and gel filtration on Sephadex G-25 Ovis aries

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-
liver
-
Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-keto-3-deoxy-D-glucose + NADP+ + H2O
-
Rattus norvegicus 2-keto-3-deoxy-D-gluconic acid + NADPH + H+
-
?
2-keto-3-deoxy-D-glucose + NADP+ + H2O
-
Ovis aries 2-keto-3-deoxy-D-gluconic acid + NADPH + H+
-
?
2-keto-3-deoxy-D-glucose + NADP+ + H2O
-
Ovis aries 2-keto-3-deoxy-D-gluconate + NADPH + H+
-
r
2-oxoaldehydes + NADP+ + H2O enzyme from sheep or rat liver also active with NAD+, see also EC 1.2.1.23 Rattus norvegicus 2-oxo acids + NADPH
-
?
2-oxoaldehydes + NADP+ + H2O enzyme from sheep or rat liver also active with NAD+, see also EC 1.2.1.23 Ovis aries 2-oxo acids + NADPH
-
?
methylglyoxal + NADP+ + H2O
-
Rattus norvegicus pyruvate + NADPH + H+
-
?
methylglyoxal + NADP+ + H2O
-
Ovis aries pyruvate + NADPH + H+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+ enzyme from sheep or rat liver, see also EC 1.2.1.23 Rattus norvegicus
NAD+ enzyme from sheep or rat liver, see also EC 1.2.1.23 Ovis aries
NADP+
-
Rattus norvegicus
NADP+
-
Ovis aries