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Literature summary for 1.2.1.47 extracted from
- Measurement of carnitine biosynthesis enzyme activities by tandem mass spectrometry: differences between the mouse and the rat (2006), Anal. Biochem., 354, 132-139.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-trimethylaminobutyraldehyde + NAD+ | Mus musculus | - |
4-trimethylaminobutanoate + NADH + H+ | - |
? |  |
| 4-trimethylaminobutyraldehyde + NAD+ | Rattus norvegicus | - |
4-trimethylaminobutanoate + NADH + H+ | - |
? | |
| 4-trimethylammoniobutanal + NAD+ + H2O | Mus musculus | - |
4-trimethylammoniobutanoate + NADH + 2 H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | low activity | Mus musculus | - |
| brain | low activity | Rattus norvegicus | - |
| heart | - |
Mus musculus | - |
| heart | low activity | Mus musculus | - |
| heart | medium activity | Rattus norvegicus | - |
| kidney | - |
Mus musculus | - |
| kidney | high activity | Mus musculus | - |
| kidney | high activity | Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| liver | highest activity | Mus musculus | - |
| liver | highest activity | Rattus norvegicus | - |
| muscle | - |
Mus musculus | - |
| muscle | low activity | Rattus norvegicus | - |
| muscle | very low activity | Mus musculus | - |
| testis | - |
Mus musculus | - |
| testis | high activity | Mus musculus | - |
| testis | high activity | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0000077 | - |
muscle | Mus musculus |
| 0.000179 | - |
heart | Mus musculus |
| 0.000298 | - |
brain | Mus musculus |
| 0.001445 | - |
kidney | Mus musculus |
| 0.001698 | - |
testis | Mus musculus |
| 0.002138 | - |
liver | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-trimethylaminobutyraldehyde + NAD+ | - |
Mus musculus | 4-trimethylaminobutanoate + NADH + H+ | - |
? | |
| 4-trimethylaminobutyraldehyde + NAD+ | - |
Rattus norvegicus | 4-trimethylaminobutanoate + NADH + H+ | - |
? | |
| 4-trimethylammoniobutanal + NAD+ + H2O | - |
Mus musculus | 4-trimethylammoniobutanoate + NADH + 2 H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 4-trimethylaminobutyraldehyde dehydrogenase | - |
Mus musculus |
| 4-trimethylammoniobutyraldehyde dehydrogenase | - |
Mus musculus |
| carnitine biosynthesis enzyme | - |
Mus musculus |
| TMABA dehydrogenase | - |
Mus musculus |
| TMABA dehydrogenase | - |
Rattus norvegicus |
| TMABA-DH | - |
Mus musculus |
| TMABA-DH | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
TMABA-DH activity assay | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
TMABA-DH activity assay | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Mus musculus | |
| NAD+ | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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