Application | Comment | Organism |
---|---|---|
medicine | ALDH3A1 contributes to the detoxification of various aldehydes produced in response to oxidative stress | Mammalia |
medicine | ALDH3A1 contributes to the detoxification of various aldehydes produced in response to oxidative stress | Mus musculus |
medicine | ALDH3A1 contributes to the detoxification of various aldehydes produced in response to oxidative stress | Homo sapiens |
medicine | ALDH3A1 contributes to the detoxification of various aldehydes produced in response to oxidative stress | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | ALDH3A1 is inactivated and covalently cross-linked by direct UV-exposure | Homo sapiens | |
additional information | ALDH3A1 is inactivated and covalently cross-linked by direct UV-exposure | Mammalia | |
additional information | ALDH3A1 is inactivated and covalently cross-linked by direct UV-exposure | Mus musculus | |
additional information | ALDH3A1 is inactivated and covalently cross-linked by direct UV-exposure | Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.012 | - |
trans-2-nonenal | purified ALDH3A1 | Mammalia | |
0.012 | - |
trans-2-nonenal | purified ALDH3A1 | Mus musculus | |
0.012 | - |
trans-2-nonenal | purified ALDH3A1 | Homo sapiens | |
0.012 | - |
trans-2-nonenal | purified ALDH3A1 | Oryctolagus cuniculus | |
0.035 | - |
trans-2-octenal | purified ALDH3A1 | Mammalia | |
0.035 | - |
trans-2-octenal | purified ALDH3A1 | Mus musculus | |
0.035 | - |
trans-2-octenal | purified ALDH3A1 | Homo sapiens | |
0.035 | - |
trans-2-octenal | purified ALDH3A1 | Oryctolagus cuniculus | |
0.045 | - |
4-hydroxy-2-nonenal | purified recombinant human ALDH3A1 | Mammalia | |
0.045 | - |
4-hydroxy-2-nonenal | purified recombinant human ALDH3A1 | Mus musculus | |
0.045 | - |
4-hydroxy-2-nonenal | purified recombinant human ALDH3A1 | Homo sapiens | |
0.045 | - |
4-hydroxy-2-nonenal | purified recombinant human ALDH3A1 | Oryctolagus cuniculus | |
0.056 | - |
4-hydroxy-2-nonenal | in the cytosolic extracts of the ALDH3A1-transfected HCE cells | Mammalia | |
0.056 | - |
4-hydroxy-2-nonenal | in the cytosolic extracts of the ALDH3A1-transfected HCE cells | Mus musculus | |
0.056 | - |
4-hydroxy-2-nonenal | in the cytosolic extracts of the ALDH3A1-transfected HCE cells | Homo sapiens | |
0.056 | - |
4-hydroxy-2-nonenal | in the cytosolic extracts of the ALDH3A1-transfected HCE cells | Oryctolagus cuniculus | |
0.155 | - |
trans-2-hexenal | purified ALDH3A1 | Mammalia | |
0.155 | - |
trans-2-hexenal | purified ALDH3A1 | Mus musculus | |
0.155 | - |
trans-2-hexenal | purified ALDH3A1 | Homo sapiens | |
0.155 | - |
trans-2-hexenal | purified ALDH3A1 | Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mammalia | 5829 | - |
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Oryctolagus cuniculus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
an aldehyde + NADP+ + H2O | Mammalia | - |
an acid + NADPH + H+ | - |
? | |
an aldehyde + NADP+ + H2O | Mus musculus | - |
an acid + NADPH + H+ | - |
? | |
an aldehyde + NADP+ + H2O | Homo sapiens | - |
an acid + NADPH + H+ | - |
? | |
an aldehyde + NADP+ + H2O | Oryctolagus cuniculus | - |
an acid + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mammalia | - |
- |
- |
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cornea | - |
Mammalia | - |
HCE cell | - |
Homo sapiens | - |
NCTC 2544 cell | skin keratinocyte | Homo sapiens | - |
RAW-264.7 cell | murine macrophages | Mus musculus | - |
TRK-43 cell | cultured rabbit stromal fibroblasts | Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxy-2-nonenal + NADP+ + H2O | - |
Mammalia | (2E)-4-hydroxynon-2-enoate + NADPH + H+ | - |
? | |
4-hydroxy-2-nonenal + NADP+ + H2O | - |
Mus musculus | (2E)-4-hydroxynon-2-enoate + NADPH + H+ | - |
? | |
4-hydroxy-2-nonenal + NADP+ + H2O | - |
Homo sapiens | (2E)-4-hydroxynon-2-enoate + NADPH + H+ | - |
? | |
4-hydroxy-2-nonenal + NADP+ + H2O | - |
Oryctolagus cuniculus | (2E)-4-hydroxynon-2-enoate + NADPH + H+ | - |
? | |
an aldehyde + NADP+ + H2O | - |
Mammalia | an acid + NADPH + H+ | - |
? | |
an aldehyde + NADP+ + H2O | - |
Mus musculus | an acid + NADPH + H+ | - |
? | |
an aldehyde + NADP+ + H2O | - |
Homo sapiens | an acid + NADPH + H+ | - |
? | |
an aldehyde + NADP+ + H2O | - |
Oryctolagus cuniculus | an acid + NADPH + H+ | - |
? | |
trans-2-hexenal + NADP+ + H2O | - |
Mammalia | (2E)-hex-2-enoate + NADPH + H+ | - |
? | |
trans-2-hexenal + NADP+ + H2O | - |
Mus musculus | (2E)-hex-2-enoate + NADPH + H+ | - |
? | |
trans-2-hexenal + NADP+ + H2O | - |
Homo sapiens | (2E)-hex-2-enoate + NADPH + H+ | - |
? | |
trans-2-hexenal + NADP+ + H2O | - |
Oryctolagus cuniculus | (2E)-hex-2-enoate + NADPH + H+ | - |
? | |
trans-2-nonenal + NADP+ + H2O | - |
Mammalia | (2E)-non-2-enoate + NADPH + H+ | - |
? | |
trans-2-nonenal + NADP+ + H2O | - |
Mus musculus | (2E)-non-2-enoate + NADPH + H+ | - |
? | |
trans-2-nonenal + NADP+ + H2O | - |
Homo sapiens | (2E)-non-2-enoate + NADPH + H+ | - |
? | |
trans-2-nonenal + NADP+ + H2O | - |
Oryctolagus cuniculus | (2E)-non-2-enoate + NADPH + H+ | - |
? | |
trans-2-octenal + NADP+ + H2O | - |
Mammalia | (2E)-oct-2-enoate + NADPH + H+ | - |
? | |
trans-2-octenal + NADP+ + H2O | - |
Mus musculus | (2E)-oct-2-enoate + NADPH + H+ | - |
? | |
trans-2-octenal + NADP+ + H2O | - |
Homo sapiens | (2E)-oct-2-enoate + NADPH + H+ | - |
? | |
trans-2-octenal + NADP+ + H2O | - |
Oryctolagus cuniculus | (2E)-oct-2-enoate + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldehyde dehydrogenase (NADP+) | - |
Mammalia |
aldehyde dehydrogenase (NADP+) | - |
Mus musculus |
aldehyde dehydrogenase (NADP+) | - |
Homo sapiens |
aldehyde dehydrogenase (NADP+) | - |
Oryctolagus cuniculus |
aldehyde dehydrogenase 3A1 | - |
Mammalia |
aldehyde dehydrogenase 3A1 | - |
Mus musculus |
aldehyde dehydrogenase 3A1 | - |
Homo sapiens |
aldehyde dehydrogenase 3A1 | - |
Oryctolagus cuniculus |
ALDH3A1 | - |
Mammalia |
ALDH3A1 | - |
Mus musculus |
ALDH3A1 | - |
Homo sapiens |
ALDH3A1 | - |
Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mammalia | |
NADPH | - |
Mus musculus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Oryctolagus cuniculus |