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Literature summary for 1.2.1.39 extracted from

  • Koma, D.; Yamanaka, H.; Moriyoshi, K.; Ohmoto, T.; Sakai, K.
    Production of aromatic compounds by metabolically engineered Escherichia coli with an expanded shikimate pathway (2012), Appl. Environ. Microbiol., 78, 6203-6216.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-hydroxyphenylacetaldehyde + NAD+ + H2O Escherichia coli
-
4-hydroxyphenylacetate + NADH + H+
-
?
phenylacetaldehyde + NAD+ + H2O Escherichia coli
-
phenylacetate + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli P80668 BW25113
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxyphenylacetaldehyde + NAD+ + H2O
-
Escherichia coli 4-hydroxyphenylacetate + NADH + H+
-
?
phenylacetaldehyde + NAD+ + H2O
-
Escherichia coli phenylacetate + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
feaB
-
Escherichia coli
PAAL dehydrogenase
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Escherichia coli

General Information

General Information Comment Organism
malfunction deletion of feaB gene results in increased desired aromatic compounds with decreased by-products. 2-Phenylethanol is not degraded by a feaB-deficient strain Escherichia coli