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Literature summary for 1.2.1.39 extracted from

  • Rodriguez-Zavala, J.S.; Allali-Hassani, A.; Weiner, H.
    Characterization of E. coli tetrameric aldehyde dehydrogenases with atypical properties compared to other aldehyde dehydrogenases (2006), Protein Sci., 15, 1387-1396.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0056
-
hexanal pH 7.5 Escherichia coli
0.0066
-
Heptanal pH 7.5 Escherichia coli
0.008
-
benzaldehyde pH 7.5 Escherichia coli
0.0116
-
phenylacetaldehyde pH 7.5 Escherichia coli
0.035
-
NAD+ pH 7.5, cosubstrate: propionaldehyde Escherichia coli
0.07
-
propionaldehyde pH 7.5 Escherichia coli
0.22
-
NADP+ pH 7.5, cosubstrate: propionaldehyde Escherichia coli
2.15
-
acetaldehyde pH 7.5 Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
210700
-
gel filtration Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phenylacetaldehyde + NAD+ + H2O Escherichia coli the enzyme participates in metabolism of phenylalanine phenylacetate + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NAD+ + H2O
-
Escherichia coli acetate + NADH + H+
-
?
benzaldehyde + NAD+ + H2O
-
Escherichia coli benzoate + NADH + H+
-
?
heptanal + NAD+ + H2O
-
Escherichia coli heptanoate + NADH
-
?
hexanal + NAD+ + H2O
-
Escherichia coli hexanoate + NADH + H+
-
?
phenylacetaldehyde + NAD+ + H2O the enzyme participates in metabolism of phenylalanine Escherichia coli phenylacetate + NADH + H+
-
?
phenylacetaldehyde + NAD+ + H2O rate-limiting step is the hydride transfer Escherichia coli phenylacetate + NADH + H+
-
?
phenylacetaldehyde + NADP+ + H2O
-
Escherichia coli phenylacetate + NADPH + H+
-
?
propionaldehyde + NAD+ + H2O
-
Escherichia coli propionate + NADH
-
?

Subunits

Subunits Comment Organism
tetramer
-
Escherichia coli

Synonyms

Synonyms Comment Organism
PAD
-
Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.16
-
benzaldehyde pH 7.5 Escherichia coli
3.5
-
NAD+ pH 7.5, cosubstrate: propionaldehyde Escherichia coli
9
-
NADP+ pH 7.5, cosubstrate: propionaldehyde Escherichia coli
14.5
-
acetaldehyde pH 7.5 Escherichia coli
20.17
-
NAD+ pH 7.5, cosubstrate: propionaldehyde Escherichia coli
20.8
-
propionaldehyde pH 7.5 Escherichia coli
21.8
-
hexanal pH 7.5 Escherichia coli
26.7
-
Heptanal pH 7.5 Escherichia coli
96.8
-
phenylacetaldehyde pH 7.5 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NAD+ active with NAD+ and NADP+, preference for NAD+. kcat/Km for NAD+ with propionaldehyde as cosubstrate is 34700 Escherichia coli
NADP+ active with NAD+ and NADP+, preference for NAD+. kcat/Km for NADP+ with propionaldehyde is 2460 Escherichia coli