Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
retinal + NAD+ + H2O | Mus musculus | - |
retinoate + NADH + 2 H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dendritic cell | isoform RALDH2 is dominantly expressed in dendritic cells | Mus musculus | - |
intestinal epithelial cell | isoform RALDH1 is dominantly expressed in intestinal epithelial cells | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
retinal + NAD+ + H2O | - |
Mus musculus | retinoate + NADH + 2 H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RalDH1 | isoform | Mus musculus |
RALDH2 | isoform | Mus musculus |
retinaldehyde dehydrogenase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | ablation of retinoic acid signaling in host dencritic cells by deletion of isoform RALDH2 protects mice from acute graft-versus-host disease. Isoform RALDH1 deletion fails to reduce acute graft-versus-host disease | Mus musculus |
physiological function | isoform RALDH2 expression in dendritic cells is critical to control acute graft-versus-host disease lethality | Mus musculus |