Literature summary for 1.2.1.36 extracted from

Hu, H.; Xu, L.; Luo, S.J.; Xiang, T.; Chen, Y.; Cao, Z.R.; Zhang, Y.J.; Mo, Z.; Wang, Y.; Meng, D.F.; Yu, L.; Lin, L.Z.; Zhang, S.J.
Retinal dehydrogenase 5 (RHD5) attenuates metastasis via regulating HIPPO/YAP signaling pathway in hepatocellular carcinoma (2020), Int. J. Med. Sci., 17, 1897-1908 .

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Application

Application	Comment	Organism
medicine	low retinal dehydrogenase 5 expression is associated with metastasis and poor patient prognosis	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
retinal + NAD+ + H2O	Homo sapiens	-	retinoate + NADH + 2 H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatoma cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
retinal + NAD+ + H2O	-	Homo sapiens	retinoate + NADH + 2 H+	-	?

Synonyms

Synonyms	Comment	Organism
RDH5	-	Homo sapiens
retinal dehydrogenase 5	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	retinal dehydrogenase 5 is significantly downregulated in hepatocellular carcinoma tissues	down

General Information

General Information	Comment	Organism
physiological function	retinal dehydrogenase 5 is an important enzyme in the visual cycle and plays a crucial role in suppressing proliferation and metastasis in hepatocellular carcinoma	Homo sapiens

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Release 2023.1 (January 2023)