Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.2.1.36 extracted from

  • Ohoka, Y.; Yokota-Nakatsuma, A.; Maeda, N.; Takeuchi, H.; Iwata, M.
    Retinoic acid and GM-CSF coordinately induce retinal dehydrogenase 2 (RALDH2) expression through cooperation between the RAR/RXR complex and Sp1 in dendritic cells (2014), PLoS ONE, 9, e96512 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.36

Cloned(Commentary)

Cloned (Comment) Organism
gene Aldh1a2, comprises 14 exons that are divided by 13 introns spanning more than 50 kb of genomic DNA, and it is localized on chromosome 9. CpG methylation in the Aldh1a2 promoter region inhibits Sp1-dependent Aldh1a2 promoter activation Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
retinal + NAD+ + H2O Mus musculus
-
 retinoate + NADH + 2 H+
-
 ?
retinal + NAD+ + H2O Mus musculus B10.D2 mice and C57BL/6 mice
-
 retinoate + NADH + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q62148
-
-
Mus musculus B10.D2 mice and C57BL/6 mice Q62148
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell from gut-related lymphoid organs Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
retinal + NAD+ + H2O
-
 Mus musculus retinoate + NADH + 2 H+
-
 ?
retinal + NAD+ + H2O
-
 Mus musculus B10.D2 mice and C57BL/6 mice retinoate + NADH + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
Aldh1a2
-
 Mus musculus
RALDH2
-
 Mus musculus
retinal dehydrogenase 2
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus ERK and p38 MAPK inhibitors PD98059 and SB203580 suppress GM-CSF-induced nuclear translocation of Sp1 and Aldh1a2 expression. CpG methylation in the Aldh1a2 promoter region inhibits Sp1-dependent Aldh1a2 promoter activation. Aldh1a2 transcription silencing by CpG methylation of the promoter region is not due to direct interference with Sp1 binding to the promoter region down
Mus musculus granulocyte-macrophage colony-stimulating factor (GMCSF) potently induces RALDH2 expression in dendritic cells in an retinoic acid-dependent manner, and retinoic acid alone weakly induces the expression. Retinoic acid and GM-CSF coordinately induce retinal dehydrogenase 2 (RALDH2) expression through cooperation between the RAR/RXR complex and Sp1 in dendritic cells up

General Information

General Information Comment Organism
additional information MAPK activation is required for GM-CSF-induced Aldh1a2 expression and Sp1 nuclear translocation. Sp1 participates in the Aldh1a2 expression. CpG methylation in the Aldh1a2 promoter region inhibits Sp1-dependent Aldh1a2 promoter activation. Aldh1a2 transcription silencing by CpG methylation of the promoter region is not due to direct interference with Sp1 binding to the promoter region Mus musculus
physiological function retinoic acid-producing dendritic cells play critical roles in gut immunity. Retinal dehydrogenase 2 (RALDH2) encoded by Aldh1a2 is a key enzyme for generating retinoic acid in dendritic cells Mus musculus