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Literature summary for 1.2.1.36 extracted from
- Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid (2003), J. Biol. Chem., 278, 36085-36090.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | Raldh1-/- null mutant mice show retinol clearance reduced by 7%, mutant mice are viable and fertile, and show no obvious defects, overview | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| all-trans-retinal + NAD+ + H2O | Mus musculus | second step in retinol clearance in adult mice, null mutants show retinol clearance reduced by 7%, and a lower LD50 concentration for all-trans-retinol compared to the wild-type mice | all-trans-retinoate + NADH | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| all-trans-retinal + NAD+ + H2O | - |
Mus musculus | all-trans-retinoate + NADH | - |
? | |
| all-trans-retinal + NAD+ + H2O | second step in retinol clearance in adult mice, null mutants show retinol clearance reduced by 7%, and a lower LD50 concentration for all-trans-retinol compared to the wild-type mice | Mus musculus | all-trans-retinoate + NADH | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ALDH1A1 | - |
Mus musculus |
| RalDH1 | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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