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Literature summary for 1.2.1.3 extracted from

  • Huellner, M.W.; Schrepfer, S.; Weyand, M.; Weiner, H.; Wimplinger, I.; Eschenhagen, T.; Rau, T.
    Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins (2008), FASEB J., 22, 2561-2568.
    View publication on PubMed

Application

Application Comment Organism
medicine in human capacitance vessels ALDH2 is s a key enzyme for the biotransformation of the frequently used antianginal drug nitroglycerin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-ethoxycyclopropanol
-
Homo sapiens
Chloral hydrate
-
Homo sapiens
cyanamide
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
57000
-
determined by SDS-PAGE and Western Blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
an aldehyde + NAD+ + H2O Homo sapiens
-
an acid + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
vein
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00088
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
an aldehyde + NAD+ + H2O
-
Homo sapiens an acid + NADH + H+
-
?
glyceryl trinitrate + NADH + H+
-
Homo sapiens 1,2-glyceryl dinitrate + nitrite + NAD+
-
?
propanal + NAD+ + H2O activity assay Homo sapiens propanoic acid + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
aldehyde dehydrogenase type 2
-
Homo sapiens
ALDH2
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.8
-
activity assay Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens